双参通冠方对心肌缺血再灌注模型大鼠炎症因子及血管内皮功能的影响  

Effect on Myocardial Ischemia Re-perfusion Pattern Rat Inflammatory Factor and Endangium Function

作　　者：钟伟[1,2] 王永刚[1,2] 于远望[1] 郑刚[1,2] 王礼凤[1,2] 尚俊平[1,2] 齐婧[1,2] 尤金枝[1,2] 

机构地区：[1]陕西中医学院心脑血管病研究所,陕西咸阳712000 [2]陕西中医学院第二附属医院心脑血管病中心,陕西咸阳712000

出　　处：《陕西中医学院学报》2013年第1期67-69,共3页Journal of Shaanxi College of Traditional Chinese Medicine

基　　金：国家自然科学基金(30973830;30901895);陕西省社会发展攻关项目(2010K17-01);陕西省教育厅科学研究计划(09JK415);陕西省中医药管理局中医药科研专项(lc13);陕西省第五批重点专科心脑血管病科建设项目;国家中医药管理局重点专科心血管病科建设项目

摘　　要：目的研究双参通冠方(SSTG)对心肌缺血再灌注模型大鼠炎症因子及血管内皮功能的影响。方法采用大鼠心肌缺血再灌注模型,随机分为假手术组、模型组、SSTG高剂量组和SSTG低剂量组,每组8只,灌胃给药,SSTG高剂量组8 g/kg、SSTG低剂量组4 g/kg,2次/d,连续给药14 d后检测血清NO、ET的水平和心肌组织TNF-α、IL-6、IL-8的水平。结果 与假手术组比较,模型组的TNF-α、IL-6、IL-8、ET水平均升高,差异有统计学意义(P<0.05)。与模型组比较,SSTG低剂量组和SSTG高剂量组TNF-α、IL-6、IL-8、ET水平均降低,NO升高,差异有统计学意义(P<0.05)。与SSTG低剂量组比较,SSTG高剂量组TNF-α、IL-6、IL-8、ET、NO改变更明显(P<0.05)。结论 双参通冠方对心肌缺血再灌注损伤具有一定的保护作用。其作用机制可能与抑制炎症因子反应和改善血管内皮物质释放有关。Object research on Effect of SSTG on Myocardial lschemia Re - perfusion Pattern Rat Inflammatory Factor and Endangium Function. Method apply Pattern of Rat Myocardial Ischemia Re - perfusion dividing into groups of pseudo -operation/pattern/SSTG of high dose/SSTG of low dose：8 rats are re - perused with drug in each group; SSTG of high dose is 8g/kg and SSTG of low dose is 4g/kg, 2times/day and this goes on for 14days and then test level of serum of NO/ ET and that of TNF -cL,IL- 6 ,IL- 8 of cardiac muscle tissue. Result comparing with the pseudo -operation group the level of TNF - c~ ,IL -6 ,IL - 8 ,ET of pattern is higher, the difference has statistical significance P 〈0.05 =. comparing with pattern group the level of TNF-a ,IL- 6 ,IL- 8 ,ET of SSTG of high dose and SSTG of low dose decreases, NO in- creases. The difference has statistical significance P 〈0.05 =. comparing with SSTG of low dose group, the level of TNF -a ,IL-6 ,IL-8 ,ET and NO of SSTG of high dose is much improved. P 〈0.05 =. Conclusion SSTG has function of protecting damage of Myocardial Ischemia Re - perfusion, its mechanism and function might have relation with restraining inflammatory Factor and improvement of relief from endangium

关 键 词：双参通冠方 心肌缺血再灌注 炎症因子 血管内皮 

分 类 号：R542.22[医药卫生—心血管疾病]