深圳市居民碘营养水平与血脂异常相关性的研究  

Exploratory study on the association between different iodine nutrition and the prevalence of dyslipidemia in Shenzhen City

作　　者：徐健[1] 王俊[1] 尚庆刚 刘小立[1] 彭晓琳[2] 赵立娜[3] 孙秀发[3] 

机构地区：[1]深圳市慢性病防治中心,深圳518020 [2]南山区慢性病防治院慢非科 [3]华中科技大学同济医学院公共卫生学院营养与食品卫生学系

出　　处：《卫生研究》2013年第1期14-17,共4页Journal of Hygiene Research

基　　金：国家自然科学基金项目(No.81102127,81172668)

摘　　要：目的探讨深圳市居民碘营养水平与血脂异常的流行病学关联。方法采用多阶段分层整群随机抽样方法,于2008年对深圳市2个社区326名入选对象进行了问卷调查、体格检查和实验室检测,获得有效问卷及生物样本317份。结果尿碘水平<200μg/L时,高密度脂蛋白胆固醇异常降低与尿碘表现出线性负相关(rs=-0.164,P=0.031);尿碘水平>300μg/L时,高密度脂蛋白胆固醇异常降低与尿碘表现出线性正相关(rs=0.246,P=0.013)。其他血脂指标与尿碘无显著相关性。多因素Logistic回归分析表明:高血糖、腹部肥胖为血脂异常危险因素。尿碘对血脂异常无显著性影响。结论深圳市居民碘营养水平与HDL-c异常之间可能存在U型关系。Objective To investigate the association between different iodine nutrition and the prevalence of dyslipidemia in a representative sample of subjects in Shenzhen. Method A total of 326 adults from 2 different communities in Shenzhen were included in the study. A questionnaire, physical examination and laboratory test were given to all subjects. 317 questionnaires and blood samples were effective. Results When the urine iodine concentration was less than 200μg/L, there is a reverse relationship between iodine nutrition and prevalence of HDL-c （ rS = - 0. 164, P = 0. 031 ）. When the urine iodine concentration was higher than 300μg/L, there is a positive relationship between iodine nutrition and prevalence of HDL-c （ r = 0. 246, P = 0. 013 ）. There was no significant correlation between other lipid parameters and urinary iodine concentration. Multivariate Logistic regression analysis showed that high blood glucose and abdominal obesity were significantly related to the prevalence of dyslipidemia, urine iodine concentration was no significant correlation with the prevalence of dyslipidemia. Conclusion The prevalence of dyslipidemia in Shenzhen is high, there may be a U shaped relationship between iodinenutrition and the prevalence of abnormal HDL-c level.

关 键 词：血脂异常 尿碘 腹部肥胖 

分 类 号：R181.2[医药卫生—流行病学] R151.41[医药卫生—公共卫生与预防医学]