汉族人群Trib1同源基因rs17321515多态性分布及其与血脂水平相关性研究  

SNP of rs17321515 homologous with Trib1 in Han population and its correlation with blood lipid

作　　者：兰满[1] 刘英[2] 石文伟 赵卉 许亮文[1] 谭晓华[1] 李金涛[4] 孟强[1] 石磊[1] 杨磊[1] 

机构地区：[1]杭州师范大学健康管理学院,杭州310018 [2]总参管理保障部北极寺门诊部 [3]总参管理保障部中心门诊部 [4]杭州市疾病预防控制中心健康教育所

出　　处：《卫生研究》2013年第1期82-86,共5页Journal of Hygiene Research

基　　金：杭州市科技发展计划项目(No.20090233T07)

摘　　要：目的检测Trib1同源基因rs17321515位点基因型多态性分布状况,并探索该位点多态性与不同血脂指标和血脂临床诊断结果的关系。方法采集1 014名体检者的血样,进行血脂四项指标测定,并采用MALDI-TOF质谱技术对rs17321515位点基因型进行分型检测。结果 rs17321515位点基因型构成比为:A/A∶A/G∶G/G=13.8%∶50.2%∶36.0%,等位基因频率为A∶G=38.9%∶61.1%。方差分析中,男性不同基因型的TG水平存在统计学差异(F=4.46,P=0.01),AG携带者比GG携带者的TG水平低(t=-0.29,P=0.02);Logistic回归分析表明,男性AA型携带者高TG血症患病率低于GG型(OR=0.45,P=0.04),男性AG型携带者低HDL-c血症患病率低于GG型携带者(OR=0.62,P=0.03),女性AG型携带者高TC血症患病率低于GG型携带者(OR=0.58,P=0.01)。结论 rs17321515位点等位基因频率在不同种族人群存在一定差异;该位点多态性对多个血脂指标和血脂异常临床诊断都有影响,但这种影响存在性别差异;A等位基因是血脂水平的保护因素。Objective To study on genotype distribution of rs17321515 which is homologous with Tribl and its associativity with blood lipid parameters and diagnosis. Method Collecting 1 014 blood samples to measure its lipid levels, then detecting rs17321515 locus＇s SNP by MALDI-TOF mass spectrometry technology. Results three genotypes（ A/A, A/G, G/G） proportions in the population were 13.8% , 50.2% and 36.0% ,allele frequencies were A： G = 38.9% ： 61.1%. In variance analysis, variation of TG of male was statistical significant（ F = 4.46, P = 0.01 ） , TG level of male who carriedAG is lower than GG carries （ t = 0.29, P = 0.02 ）. Logistic regression analysis showed that,hypertriglyceridemia prevalence of male who carried AA is lower than GG carries （ OR = 0.45,P = 0.04）. Low HDL-c acidosis prevalence of male who carried AG is lower than GG carries（ OR = 0.62, P = 0.03 ）. Hypercholesterolemia prevalence of female who carried AG is lower than GG carries （ OR = 0.58, P = 0.01 ）. Conclusion Allele frequencies of rs17321515 varies in different ethnic groups; The locus＇ polymorphism distribution is relevant with a certain lipid indicators and lipid diagnosis, but there exist gender differences on these relevance.

关 键 词：Trib1基因 基因多态性 血脂 遗传平衡性 

分 类 号：Q344[生物学—遗传学] R446.11[医药卫生—诊断学]