新生儿经皮胆红素与血清胆红素测定影响因素及高胆红素血症感染的临床分析  

Factors influencing determination of neonatal transcutaneous bilirubin and serum bilirubin and clinical analysis of hyperbilirubinemia

作　　者：金霆[1] 费政芳[1] 严争 

机构地区：[1]福建医科大学附属福州市第一医院检验科,福建福州350009 [2]儿科,福建福州350009

出　　处：《中华医院感染学杂志》2013年第3期590-592,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨新生儿经皮胆红素与血清胆红素测定的影响因素及高胆红素血症感染因素的临床分析。方法对发生胆红素血症250例患儿经皮胆红素值与经末梢血和血清测定的总胆红素值进行对照,同时对患儿的发病因素进行分析。结果婴儿经皮胆红素与末梢血胆红素以及血清总胆红素测定值分别为(145.6±23.5)、(148.3±20.1)、(155.2±15.2)μmol/L,差异有统计学意义(P<0.01);导致新生儿高胆红素血症的最主要因素为围产因素107例,占42.8%,感染因素81例,占32.4%,感染因素主要包括脐炎、脓疱疹、败血症、肺炎、化脓性脑膜炎、弓形体感染、巨细胞病毒感染及先天性梅毒等。结论经皮胆红素测定与血清胆红素水平具有高度相关性,感染因素占高胆红素血症病因的次位,治疗应根据感染具体病因采取不同的治疗方案。Abstract： OBJECTIVE To explore the related factors influencing the determination of the neonatal transeutaneous bilirubin and serum bilirubin and to analyze the causes of the neonatal infection hyperbiliruhinemia. METHODS The transcutaneous bilirubin value in 250 children with hyperbilirubinemia and the bilirubin value of the bypass peripheral blood and serum bilirubin value were compared and analyzed, then the predisposing factors were analyzed.RESULTS The determination values of the transcutaneous bilirubin, peripheral blood bilirubin, and total serum bilirubin were（145.6±23.5）tool/L, （148.3±20. 1）mol/L, and（155.2±15.2）/,mol/L, respectively, the differences were statistically significant（P〈0. 001 ）. There were 107 （42.8%） cases of neonates who caught the neonatal hyperbilirubinemia primarily due to the perinatal factors, 81 （a2. 4%）cases due to the infection factors. The infection factors mainly consisted of omphalitis, impetigo, septicemia, pneumonia, purulent meningitis, toxoplas- mosis infection, giant CMV infection, and congenital syphilis. CONCLUSION The determination of transcutaneous bilirubin is highly correlated with the level of serum hilirulain. The infeetion factors take a secondary place to cause the hyperbilirubinemia, the treatment should be conducted according to the specific cause by taking different treatment programs.

关 键 词：新生儿 胆红素测定 高胆红素血症 感染因素 

分 类 号：R181.32[医药卫生—流行病学]