阴沟肠杆菌在医院骨科感染中的分布及药敏分析  

Distibution of Enterobacter cloacae infections in department of orthopedics and analysis of drug susceptibility

作　　者：王向前[1] 何爱咏[1] 赵帅[1] 常晓飞[1] 

机构地区：[1]中南大学湘雅二医院骨科,湖南长沙410011

出　　处：《中华医院感染学杂志》2013年第3期680-682,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查医院骨科2007-2011年阴沟肠杆菌的分布和耐药性,并分析其相关因素,为临床治疗和预防阴沟肠杆菌感染提供参考依据。方法收集2007-2011年四肢创伤住院患者伤口分泌物标本1218份,均由临床医师严格按照无菌操作规范采集,按照标准程序进行细菌培养和药敏试验。结果共收集1218份标本,阳性标本检出154份,检出率为12.64%;除2007年外其余4年检出率均>10.00%,对亚胺培南和阿米卡星的耐药率2011年<50.00%,对青霉素、头孢类抗菌药物的耐药率均较高,发现5年其检出率和耐药率均明显增加。结论阴沟肠杆菌是骨科感染常见病原菌,常用的青霉素类及头孢菌素类耐药率较高,这与临床普遍存在的不合理使用抗菌药物密切相关,因此,临床医师应根据药敏试验合理选用抗菌药物。OBJECTIVE To investigate the isolation and the drug resistance of Enterobacter cloacae strains from the orthopedics department between 2007 and 2011,and analyze the related factors so as to provide basis for the clinical treatment and prevention of E.cloacae infections.METHODS A total of 1218 wound secretion specimens were collected from hospitalized patients with limbs trauma from 2007 to 2011.All the specimens were sampled under the rigid aseptic operation,and the bacterial culture and drug susceptibility testing were performed in accordance with the standard procedure.RESULTS Of totally 1218 specimens collected,there were 154 specimens with the E.cloacae detected positive,the detection rate was 12.64%,and the detection rates were all higher than 10.00% in the four years except 2007.The drug resistance rates to imipenem and amikacin were less than 50.00% in 2011,and the strains were highly resistant to the commonly used penicillins and cephalosporins antibiotics.The study concluded that both the detection rate and the drug resistance rate were significantly increased during the past five years.CONCLUSION E.cloacae is the prevalent pathogen causing infections in the orthopedics department and is highly resistant to the commonly used penicillin and cephalosporin antibiotics,which is closely related to the unreasonable use of antibiotics in the hospital,thus,it is necessary for the clinicians to reasonably choose antibiotics on the basis of the drug susceptibility testing.

关 键 词：阴沟肠杆菌 骨科 药敏分析 

分 类 号：R378[医药卫生—病原生物学]