^(18)FDG-PET/CT评价顺铂联合吲哚美辛及其衍生物对Lewis肺癌治疗效果的实验研究  

Experimental study of the effect of Cisplatin combined with Indomethacin and its derivatives for the treatment of Lewis lung carcinoma with ^(18)FDG-PET/CT

作　　者：高继东[1,2] 张彩霞[1] 陆国秀[1] 徐微娜[1] 于树鹏[1] 

机构地区：[1]中国医科大学附属盛京医院,沈阳110004 [2]解放军第四六三医院,沈阳110042

出　　处：《核技术》2013年第2期56-62,共7页Nuclear Techniques

基　　金：辽宁省重点实验室基金(20060919)资助

摘　　要：为评价吲哚美辛及其衍生物组胺吲哚美辛对鼠Lewis肺癌的治疗效果,建立40只Lewis肺癌昆明小鼠腋下移植瘤模型,并随机分为四组:顺铂(DDP)治疗组、顺铂+吲哚美辛(DDP+Indomethacin IN)治疗组、顺铂+组胺-吲哚美辛(DDP+His-IN)治疗组及生理盐水对照组。各组小鼠于治疗前后各行PET/CT显像及取眼眶血0.2 mL,留取肿瘤组织进行组织学检测。结果显示,治疗后不同治疗组与生理盐水对照组比较靶本比均有显著性差异(P<0.05),各组治疗后TNF-α含量均升高,以DDP+His-IN组更为显著;抑瘤率未见明显差异(P>0.05)。表明IN、His-IN与DDP联合用药抗肿瘤效果好,尤其DDP与His-IN联合应用抗肿瘤效果更佳;另外,T/B比值变化能较早反映化疗药物的抗肿瘤效果。Background： Non-steroidal anti-inflammatory drug Indomethacin have been used in the treatment of fever, pain, inflammation and rheumatic disease. In recent years, some researches have confirmed that Indomethacin have the ability of assistant therapy on many kinds of malignant tumors, such as colon cancer, gastric cancer and lung cancer. Purpose： To evaluate the effect of Cisplatin combined with Indomethacin and Histamine-Indomethacin to Lewis lung cancer. Methods： 40 male Kunming mice were used to establish Lewis lung cancer model. They were randomly divided into four groups： Cisplatin treatment group, Cisplatin＋Indomethacin treatment group, Cisplatin＋Histamine-Indomethacin treatment group and control group. Each mouse was given the PET/CT imaging and taken orbital blood for 0.2 mL before and after the treatment. Histological detection was given. Results： Ratio of targets were significantly different after the treatment, especially in Cisplatin＋Histamine-Indomethacin treatment group. Each group TNF-a levels were increased after treatment and the Cisplatin＋Histamine-Indomethacin treatment group was the most obvious. There was no obvious difference in tumor inhibiting rates. Conclusions： The results showed that Cisplatin combined with Histamine-Indomethacin could inhibit tumor growth and promote apoptosis of tumor cells better. The changes of the ratio of targets could reflect the effect of the chemotherapy drugs earlier.

关 键 词：吲哚美辛 LEWIS肺癌 TNF-α 正电子 18FDG-PET/CT 

分 类 号：R817.1[医药卫生—影像医学与核医学]