IL-17^+γδT细胞与疾病关联性的研究进展  

Research progress of IL-17 producing-γδT cell in disease

作　　者：周晓薇[1] 胡朝英[2] 张冬青[1] 

机构地区：[1]上海交通大学医学院,上海市免疫学研究所,上海200025 [2]上海市徐汇区中心医院,上海200031

出　　处：《生命科学》2013年第1期28-35,共8页Chinese Bulletin of Life Sciences

基　　金：上海市科委重点项目(10JC1408500);上海市科委重点学科(外科学)开放课题(S30204-K01);上海市免疫学研究所项目(08-A04)

摘　　要：γδT细胞是一群异质细胞,人和小鼠不同组织部位的γδT细胞亚群表型多变、功能丰富。γδT细胞经过胸腺选择,形成IL-17+γδT细胞、IFN-γ+γδT细胞或IL-4+γδT细胞,它的分化受到很多因素的调控。γδT细胞是炎症介质IL-17的重要来源,IL-17+γδT细胞可以参与多种疾病的诱发和发展,如过敏、自身免疫性疾病,甚至恶性肿瘤。此外,它们也在宿主防御中发挥保护作用,防治传染病和诱导细胞毒性T淋巴细胞对癌症的反应。就IL-17+γδT细胞的发育、分化和调节机制以及在各种疾病中的作用进行综述。γδT cells are a group of cells of high heterology, which can be divided into several phenotypic and functional categories. Through an unique thymic selection, γδT cells differentiate into IL-17 ＋~,6T cells, IFN-γ＋ γδT cells or IL-4＋γδT cells, which is influenced by many factors, γδT is a source of IL-17, which is an important mediator of inflammation. IL-17 γδTcells participate in a variety of diseases, such as allergies, autoimmune disease and malignant tumor. In addition, they also play a protective role in host defense, promoting the response of CTLs to cancer. This paper reviewed 1L-17＋γδT cell development, differentiation and regulation mechanism as well as its roles in various diseases.

关 键 词：ΓΔT细胞 IL-17 分化 感染 自身免疫性疾病 肿瘤 

分 类 号：R392.11[医药卫生—免疫学]