磁性蛋白质微胶囊的声化学法构筑  

Fabrication of Magnetic Protein Microcapsules by Sonochemical Method

作　　者：王春蕾[1,2] 闫俊涛[1,2] 钟双玲[3] 李占锋[1] 崔学军[1] 王洪艳[1] 

机构地区：[1]吉林大学化学学院,长春130012 [2]武汉工业学院化学与环境工程学院,武汉430023 [3]吉林农业大学资源与环境学院,长春130118

出　　处：《高等学校化学学报》2013年第2期462-466,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21104023);教育部博士点新教师基金(批准号:20090061120078)资助

摘　　要：通过声化学法制备了具有生物相容性的磁性蛋白质微胶囊,利用高强度超声波辐照含有油酸改性磁性的Fe3O4纳米粒子的油相与蛋白质水溶液的两相界面,只需几分钟即可得到磁性蛋白质微胶囊.这种制备蛋白质微胶囊的方法快速简便,高效环保,可将分散于油相的疏水性药物直接装载,不破坏药物.在药物靶向传输等领域具有应用性.Biocompatible magnetic protein microcapsules（MPMCs） were prepared by sonochemical method.Under high intensity ultrasonic treatment,the MPMCs were yielded at the interface between the oil liquids containing Fe3O4 nanoparticles and the protein solution within several minutes.Meanwhile,the hydrophobic drugs could be loaded into MPMCs directly via sonochemical method and the activities of proteins and drugs were not destroyed.The sonochemical technique is a very simple and cost-effective method to fabricate MPMCs as drug carriers.Such prepared MPMCs are very promising carriers for drug delivery systems and magnetic resonance imaging.

关 键 词：蛋白质微胶囊 声化学法 磁性FE3O4纳米粒子 靶向传输 

分 类 号：O631[理学—高分子化学] O644[理学—化学]