阿司匹林对环磷酰胺模型小鼠免疫功能的影响  

The effect of aspirin on immune function in cyclophosphamide model of mice

作　　者：赵英虎[1] 高莉[1] 赵恒寿 殷生章 王荣珍 王巧玲 周秀霞 

机构地区：[1]中北大学化工与环境学院,太原030051 [2]山西省动物药品与疾病防治研究技术工程中心,太谷030801

出　　处：《中国抗生素杂志》2013年第2期149-154,共6页Chinese Journal of Antibiotics

基　　金：中北大学校科学基金资助项目;山西省青年科技研究基金(2012021027-3)

摘　　要：目的研究阿司匹林对环磷酰胺模型昆明种小鼠免疫功能的影响。方法试验分为4组,依次是对照组、阿司匹林组、环磷酰胺组、环磷酰胺+阿司匹林组。MTT法检测T、B淋巴细胞和腹腔巨噬细胞的活性。结果结果显示,环磷酰胺组淋巴细胞和巨噬细胞活性都受到了抑制,尤其是胸腺T淋巴细胞的活性显著降低(P<0.05)。环磷酰胺+阿司匹林组给药后,细胞活性有增强的趋势,但结果不显著(P>0.05)。阿司匹林组小鼠血液、脾脏、胸腺的T细胞活性不同程度的都增强,但与对照组相比,差异不显著(P>0.05);B淋巴细胞的活性未见明显变化。结论研究结果提示阿司匹林可以对抗环磷酰胺对T淋巴细胞的免疫抑制作用。Objective To study the effect of Aspirin on immune function in Cyclophosphamide mice. Methods There were 4 groups including control group, Aspirin group, Cyclophosphamide group and Cyclophosphamide ＋ Aspirin group. The T and B lymphocyte and peritoneal macrophage were detected by MTT colorimetric assays. Results The lymphocyte and macrophage activity in Cyclophosphamide group were inhabited, especially the thymic lymphocyte T activity was inhibited significantly（P〈0.05）.The cytoactive of Cyclophosphamide ＋ Aspirin group was enhanced, but there was no significant effect（P〉0.05）. Aspirin enhanced the activity of T lymphocyte in blood, spleen and thymus in Immune-inhibited Mice in a short period, but there was no significant effect（P〉0.05）, and there was no significant effect on B lymphocyte activity. Conclusion This indicated that Aspirin could reduce the immune inhibition of Cyclophosphamide to T lymphocyte.

关 键 词：阿司匹林 淋巴细胞 增殖 

分 类 号：R96[医药卫生—药理学]