丽申宝与果纳芬在IVF-ET长方案的临床比较  

Comparison of the clinical efficacy between uFSH and rFSH in the long protocol of IVF-ET

作　　者：蒋元华[1] 段金良[1] 

机构地区：[1]中国人民解放军第一八一医院生殖中心,广西桂林541001

出　　处：《中国性科学》2013年第1期29-31,共3页Chinese Journal of Human Sexuality

摘　　要：目的:比较高纯度尿促性素(丽申宝,uFSH)和重组人促卵泡素(果纳芬,rFSH)在体外受精-胚胎移植/卵胞浆内单精子注射(IVF-ET/ICSI-ET)助孕中长方案患者控制性超排卵(COH)的临床疗效和安全性。方法:对2010年7月～2010年12月在我中心行IVF-ET/ICSI-ET助孕长方案患者,共367周期,COH随机分组,选择丽中宝组261周期,果纳芬组106周期,比较两组患者年龄、基础FSH.、LH、Gn用量、Gn天数、平均卵泡数、平均获卵数、平均胚胎数、平均优质胚胎数、平均移植胚胎数、妊娠率、着床率、流产率、异位妊娠率及分娩率。结果:两组患者年龄、基础FSH.、LH、Gn天数、平均卵泡数、平均获卵数、平均胚胎数、平均优质胚胎数、平均移植胚胎数均无明显差异(P>0.05),丽申宝组患者Gn用量(28.77±7.81)略大于果纳芬组(25.80±7.07)(P<0.05),丽申宝组患者平均胚胎数(7.21±3.95)略低于果纳芬组(8.37±4.38)(P<0.05),妊娠率、着床率、分娩率均低于果纳芬组,流产率、异位妊娠率均高于果纳芬组,但无统计学差异(P>0.05)。结论:丽申宝组在IVF-ET/ICSI-ET助孕长方案患者中控制性超排卵临床效果略逊于果纳芬组,其用药量稍大,平均胚胎数、妊娠率、着床率及分娩率均低于果纳芬组,但无统计学差异。Objectives： To compare the clinical efficacy and safety between highly purified uFSH and rFSH for COH patients in the long protocol of IVF - ET/ICSI - ET. Methods： Patients who had received the long protocol treatment of IVF - ET/ ICSI -ET with a total 360 cycles in our center from July to December 2010 were divided into two groups, namely, group uFSH with 261 cycles and group rFSH with 106 cycles. The two groups were compared in terms of the ages, basic FSH level, LH level, Dosage of Gn, days of Gn, average follicles, average obtained follicles, average embryos, average quality embryos, average transplanted embryos, pregnancy rate, implantation rate, abortion rate, ectopie pregnancy rate and child birth rate. Results： There was no significant difference between the two groups with regard to the ages, basic FSH, LH, Dosage of Gn, days of Gn, average follicles, average obtained follicles, average embryos, average quality embryos and average transplanted embryos. The dosage of Gn in group uFSH （28.77 ± 7.81 ） was slightly higher than that of the rFSH group （ 25.80 ± 7.07 ） （ P 〈 0.05 ）. The average embryos （7.21 ±3.95 ） in group uFSH were slightly less than those in the rFSH group（8.37 ± 4.38） （P 〈 0.05）. The pregnancy rate, implantation rate and birth rate were lower and the abortion rate and eetopic pregnancy rate were higher in uFSH group than in the rFSH group. Conclusions： The clinical efficiency of the uFSH in the long protocol of IVF - ET/ICSI - ET was slightly inferior to that of the rFSH group. The dosage of uFSH was high and all the average embryos, pregnancy rate, implantation rate and birth rate in uFSH groups were lower than those in the rFSH group, but without significant statistical differences.

关 键 词：丽申宝 果纳芬 控制性超排卵 体外受精-胚胎移植 

分 类 号：R711.6[医药卫生—妇产科学]