巨噬细胞选择性活化的信号通路及其干预措施的研究进展  

Research progress in signal transduction of macrophage M2 polarization and intervention measures

作　　者：赵娜[1] 李素梅[1] 

机构地区：[1]安徽医科大学附属安徽省立医院内分泌科,合肥230001

出　　处：《微生物学免疫学进展》2012年第6期73-77,共5页Progress In Microbiology and Immunology

摘　　要：巨噬细胞在不同环境刺激下分化为经典活化巨噬细胞和选择性活化巨噬细胞,巨噬细胞选择性活化的信号通路包括:JAK/STAT6途径、M2分化成熟的转录调节途径(KLF4的转录调节,PPARs的转录调节)以及Jmjd3表观遗传学调节途径。选择性活化对机体而言是一种保护机制,可以依据上述分子理论予以干预,如:细胞因子、PPARγ完全性激动剂、PPARγ部分性激动剂、微量元素硒以及生活方式等通过IL-4/STAT6/PPARγ途径促进巨噬细胞选择性极化。对巨噬细胞选择性活化的信号通路及其促进措施进行了简述。It is well established that macrophages respond to the different environment in a polarized manner,which is roughly classified into two poles,classically activated macrophages（classically activated macrophage,CAMs or M1） and alternatively activated macrophages（alternatively activated macrophage,AAMs or M2）.M2 polarization is induced through the JAK/STAT6 signaling way,the transcription regulation by KLF4,PPARs and Jmjd3.The intervention measures of M2 polarization is linked to numerous beneficial effects in the contexts of inflammation,including the cytokines,PPARγ full agonists,PPARγ partial agonists,micronutrient（selenium）and live-style.In this review,the signal transduction of M2 polarization and the intervention measures is introduced.

关 键 词：巨噬细胞 选择性活化巨噬细胞(M2) 信号通路 促进措施 

分 类 号：R392.12[医药卫生—免疫学]