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作 者:刘果[1] 孙慧怡[2] 周波[2] 刘大铭[2] 王新月[2]
机构地区:[1]北京中医药大学基础医学院,北京100029 [2]北京中医药大学东直门医院
出 处:《北京中医药大学学报》2013年第1期51-55,共5页Journal of Beijing University of Traditional Chinese Medicine
基 金:国家科技部“973”计划项目(No.2009CB522705);国家自然科学基金项目(No.30572390)
摘 要:目的评价益气活血解毒中药复方对溃疡性结肠炎(UC)慢性复发型活动期和慢性持续型的临床疗效及抗复发情况。方法采用随机、阳性对照的方法,以门诊和住院患者为研究对象,选择溃疡性结肠炎慢性复发型活动期和慢性持续型病例60例,治疗组给予益气活血解毒中药加减治疗,对照组给予柳氮磺胺吡啶(SASP)(4~6 g/d)治疗。疗程均为3个月,对有效病例随访6个月,主要观察临床综合疗效、复发率、中医证候疗效、临床活动指数及内镜指数的变化。结果治疗3个月后,治疗组临床综合疗效优于对照组,两组完全缓解率及总有效率亦经统计学检验,存在显著差异。治疗组6个月复发率明显低于对照组,治疗组中医证候积分的近期及远期改善、临床活动指数、内镜指数、近期疗效及远期疗效均优于对照组。结论益气活血解毒中药复方对溃疡性结肠炎临床疗效肯定,尤其在抗复发方面较柳氮磺胺吡啶存在着明显优势。Objective To evaluate the curative effect and anti-recurrence effect of Chinese compound formula with the actions of tonifying qi, activating blood and resolving toxin on chronic recurrent ulcerative colitis (UC) at active phase and chronic persistent phase. Methods Randomized and positive control method was applied and clinical and hospitalized patients were taken as study objects, 60 patients with chronic recurrent UC at active phase and chronic persistent UC were selected. The treatment group was given Chinese medieinals with the actions of tonifying qi, activating blood and resolving toxin and control group was given sulfasalazine (SASP, 4 ~ 6 g/d). A therapeutic course was 3 months and the cases with curative effect were followed up for 6 months. The clinical comprehensive curative effect, recurrent rate, curative effect on TCM syndromes, and changes of clinical activity index and endoscopic index were observed. Results After treatment for 3 months, the clinical comprehensive curative effect was higher in treatment group than that in control group. The complete remission rate and total effective rate had significant difference between two groups after statistical test. The 6-month recurrent rate was significantly lower in treatment group than that in control group. The short-term and long-term improvement of TCM syndrome integral, clinical activity index, endoscopic index and short-term and long-term curative effects were all better in treatment group than those in control group. Condusion Chinese compound formula
分 类 号:R259.741[医药卫生—中西医结合]
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