羧甲基-β-环糊精为手性选择剂拆分盐酸尼卡地平等6种药物对映体  

Enantiomeric separation of six drugs by high performance capillary electrophoresis

作　　者：胡艳丽[1] 赵旻[1] 郭雯雯[1] 张丽娟[1] 徐淑英[1] 郭兴杰[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2013年第2期114-119,共6页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(41330166)

摘　　要：目的建立高效毛细管电泳法分离盐酸尼卡地平等6种药物对映体。方法采用未涂层熔融石英毛细管柱,30 mmol.L-1磷酸盐缓冲液作为背景电解质,手性选择剂为羧甲基-β-环糊精(CM-β-CD)。结果在最佳条件下,盐酸尼卡地平、盐酸曲马多、酮康唑、氧氟沙星、阿替洛尔、盐酸特布他林的分离度(R)分别为3.44、1.50、2.37、7.50、1.83和2.80。结论 CM-β-CD对6种药物对映体均有较好的对映体选择性。该分离方法操作简单,重现性好。Objective To establish a method of high performance capillary electrophoresis for the chiral sepa- rations of six drugs. Methods The separations of enantiomers were performed in an untreated fused-silica capillary tube, using CM-fl-CD as chiral selectors, buffer of 30 mmol. L- NaH2PO4. Results Under the opti- mal conditions, the resolutions of nicardipine hydrochloride, tramadol hydrochloride, ketoconazole, ofloxacin, atenolol and terbutaline hydrochloride were 3.44,1.50,2.37,7.50,1.83 and 2. 80, respectively. Conclu- sions CM-fl-CD is highly enantioselective for the six drugs. The method is simple, fast with an improved re- producibility.

关 键 词：毛细管电泳 羧甲基-β-环糊精 药物对映体 手性分离 

分 类 号：R917[医药卫生—药物分析学]