透明质酸介导姜黄素靶向脂质体的制备及质量评价  

Study on preparation of hyaluronic acid-targeted curcumin liposome and its quality evaluation

作　　者：赵怡[1] 孟路华[2] 王驰[2] 

机构地区：[1]重庆医科大学生命科学研究院,重庆400016 [2]重庆医科大学药学院,重庆400016

出　　处：《现代医药卫生》2013年第2期169-171,174,共4页Journal of Modern Medicine & Health

摘　　要：目的制备透明质酸-姜黄素脂质体(HA-CUR-L),并考察其包封率及质量评价。方法采用逆相蒸发法制备HA-CUR-L,测定其包封率、HA结合率、形态分布、粒径及体外释放度。结果脂质体平均包封率为88.75%,HA结合率为71.69%;脂质体平均粒径为160 nm;36 h后,累计释药量为82.26%。结论选用逆相蒸发法制备HA-CUR-L,处方合理,工艺简便可行,包封率高。Objective To preparare hyaluronic acid-curcumin-liposome（HA-CUR-L）and to investigate the encapsulation rate and the quality evaluation.Methods HA-CUR-L was prepared by the reversed-phase evaporation method,and the encapsulation rate,HA-binding rate,form distribution,particle size and in vitro release were detected.Results The average entrapment rate of HA-CUR-L was 88.75%,the binding rate of HA was 71.69% and the particle size was 160 nm.The total accumulative in vitro release amount was 82.26% after 36 h.Conclusion Selecting the reversed-phase evaporation method for optimizing HA-CUR-L is reasonable in prescription,convinient and feasible technology with high encapsulation rate.

关 键 词：透明质酸 姜黄素 脂质体 质量控制 

分 类 号：R285[医药卫生—中药学]