E-钙粘蛋白在胚胎停育患者绒毛和蜕膜中的差异性表达  

E-cadherin(E-Cad) differentially expressed in Villi and decidua from embryos stopped sterile

作　　者：李三阳[1] 李怡[1] 苗卓[1] 张哲[1] 尹国武[1] 

机构地区：[1]第四军医大学唐都医院,西安710038

出　　处：《陕西医学杂志》2013年第2期131-133,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(No:81100440;31000660);陕西省攻关项目(2011K15-02-04)

摘　　要：目的:探讨E-钙粘蛋白(E-Cad)与胚胎停育的关系。方法:选取胚胎停止发育妇女为实验组,同期正常早孕自愿要求流产的妇女为对照组,分别留取其绒毛和蜕膜组织标本,采用荧光实时定量PCR(Real time-PCR)对标本E-Cad mRNA转录水平进行分析。结果:在绒毛标本中,E-Cad在实验组中mRNA表达水平(0.875±0.07)显著高于对照组(0.337±0.11);在蜕膜标本中,实验组E-Cad mRNA的表达水平(0.927±0.12)显著高于对照组(0.512±0.08)。结论:E-Cad的差异表达可能参与了胚胎停育的发生及发展,蜕膜和绒毛组织中E-Cad的高表达可能是导致早期胚胎停育的原因之一。Objective： The relationship between E-Cad and embryos damage. Methods：Select embryos damage women as the experimental group, the same period in normal early pregnancy voluntarily request the abortion of women as a control group,respectively,leaving whichever villi and decidual tissue, using a real-time quantitative PCR （RT-PCR） of specimens E-Cad mRNA transcription level analysis. Results l Villus samples, E-Cad expression levels in the experimental group（0. 875±0.07）was significantly higher than that in the control group （0. 337±0. 11）. in the decidual specimens, E-Cad mRNA expression levels of the experimental group（0. 927±0.12）was signifi- candy higher than that in the control group（0. 512 ±0.08）. Conclusion： The differences in the expression of E-Cad may be involved in the occurrence and development of the embryos damage. Decidua and chorionic villi high expres- sion of E-Cad probably one of the reasons why early embryos damage.

关 键 词：胚胎发育 桥粒钙粘蛋白 蜕膜 绒毛膜绒毛 

分 类 号：R711[医药卫生—妇产科学]