九节龙皂苷衍生物的合成及其抗肿瘤活性  

Synthesis and Anti-tumor Activities of Ardipusilloside Derivatives

作　　者：王丽[1] 王荣 校鑫 匡永清[1] 王晓娟 

机构地区：[1]湖南大学化学化工学院,长沙410082 [2]第四军医大学口腔医院

出　　处：《中国药师》2013年第1期6-8,共3页China Pharmacist

基　　金：国家自然科学基金项目(编号:30973623);陕西省资源主导型产业关键技术(链)项目(编号:2011KTCL03-01);第四军医大学优秀文职人员培养基金(编号:00003383)

摘　　要：目的:合成九节龙皂苷衍生物并研究其抗肿瘤活性。方法:以九节龙皂苷Ⅰ为先导物,对其30位醛基进行结构修饰,合成一系列衍生物,通过体外细胞培养方法检测其对9种常见肿瘤细胞系的抗肿瘤活性。结果:获得了3个新的皂苷修饰物,其中化合物1和化合物3对常见的9种瘤株的IC_(50)与原皂苷相比均降低(P<0.05),化合物1和化合物3对肿瘤细胞的抑制率较原皂苷增强。结论:通过对九节龙皂苷进行结构修饰,能增加其抗肿瘤活性。Objective：To synthesize ardipusilloside（ADS） derivatives and evaluate their anti-tumor activities.Method：A series of chemical compounds were synthesized by the modification of 30-aldehyde group in ardipusilloside,and the anti-tumor activities of the three compounds were studied.Result：Three new compounds were synthesized,and two of which could enhance the anti-tumor activity when compared with ADS.Conclusion：The study establishes a synthetic method for ardipusilloside derivatives and the anti-tumor activities are worthy of further study.

关 键 词：九节龙皂苷 结构修饰 抗肿瘤活性 

分 类 号：R284.1[医药卫生—中药学]