马来酸氟吡汀固体分散体的制备及体外溶出  

Study on the Preparation and Dissolution of Flupirtine Maleate Solid Dispersions

作　　者：胡静波[1] 胡晓[2] 苏卫[1] 董少华[2] 陈鹰[1] 

机构地区：[1]南方医科大学,广州510515 [2]广州军区武汉总医院

出　　处：《中国药师》2013年第1期73-75,共3页China Pharmacist

摘　　要：目的:制备马来酸氟吡汀-PEG 6000固体分散体以加快药物的体外溶出速度。方法:以PEG 6000为药物载体,采用熔融法制备马来酸氟吡汀固体分散体,采用X-射线衍射法和差示扫描量热法(DSC)观察药物在载体中的存在状态。结果:马来酸氟吡汀以分子状态存在于固体分散体中;药物与载体的比例为1:4时,所制备的固体分散体具有最高的溶出度。结论:固体分散体能显著提高药物溶出度和溶出速率。Objective：To prepare flupirtine maleate solid dispersions to improve the in vitro release of the drug.Method：Flupirtine maleate solid dispersions were prepared by melting method using PEG 6000 as the carrier.The status of flupirtine maleate in the carrier was determined by X-ray diffraction and differential scanning calorimetry（DSC）.Result：Flupirtine maleate in the solid dispersions could be dispersed with molecular state.The dissolution of flupirtine maleate solid dispersions reached the highest with the ratio of drug and carrier of 1：4.Conclusion：Both the dissolution and dissolution rate in vitro of the drug are increased by the solid dispersions.

关 键 词：马来酸氟吡汀 固体分散体 X-射线衍射 差示扫描量热法 体外溶出 

分 类 号：R944.9[医药卫生—药剂学]