我国孕妇乙肝表面抗原阳性率的Meta分析  

Meta-analysis on the positive rate of hepatitis B surface antigen among pregnant women in China

作　　者：石果[1,2] 张顺祥[2] 

机构地区：[1]郑州大学公共卫生学院,河南郑州450001 [2]深圳市疾病预防控制中心,深圳518055

出　　处：《中国预防医学杂志》2013年第1期26-30,共5页Chinese Preventive Medicine

基　　金：国家"十一五"科技重大专项资助(2008ZX10002-001)

摘　　要：目的采用Meta分析系统评价我国孕妇2002-2012年乙肝表面抗原(HBsAg)阳性率情况。方法系统检索中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库和万方数据资源系统及PubMed中2002年1月至2012年1月发表的有关中国孕妇HBsAg阳性率的研究报道,分别用广义倒方差模型及MetaAnalyst3.13软件提供的随机效应模型估计孕妇HBsAg合并阳性率。结果共纳入文献35篇,总样本量224 029例,经广义倒方差模型加权合并后的阳性率为7.91%(95%CI:7.78%～8.03%),MetaAn-alyst合并后的阳性率7.6%(95%CI:6.5%～8.7%),因纳入研究结果具有异质性,采用MetaAnalyst提供的随机效应模型获得的结果更为合适,即我国孕妇HBsAg阳性率加权合并值为7.60%,95%置信区间为6.50%～8.70%。结论孕妇HBsAg阳性率的Meta分析结果与全国流行病学调查结果相近,可以为乙肝母婴传播的阻断策略制定提供借鉴。Objective To systematically evaluate the national positive rate of hepatitis B surface antigen（HBsAg） among pregnant women in China by meta-analysis.Methods Publications regarding the positive rate of HBsAg among pregnant women between 2002 and 2012 were extracted from China National Knowledge Infrastructure（CNKI）,Chinese science technology journal database（VIP）,Wanfang database and PubMed,The Meta positive rate was estimated using generic inverse variance model and the random effect model provided by MetaAnalyst software.Results Thirty-five papers were retrieved with a total sample size of 224 029.The weighted positive rate was 7.91%（95% CI：7.78%-8.03%） estimated by generic inverse variance model and 7.60%（95% CI：6.50%-8.70%）by the random effect model provided by MetaAnalyst software.Because of the heterogeneity of included studies,the result acquired by MetaAnalyst software was more accurate.Conclusions The result of the meta-analysis is almost consistent with the result of national epidemiological survey,indicating that Meta analysis is reliable,which provides key parameter for making strategies to prevent maternal-infantile transmission.

关 键 词：孕妇 乙肝表面抗原 阳性率 META分析 

分 类 号：R446.6[医药卫生—诊断学]