非那雄胺的不同用药方式对前列腺经尿道电切除术影响的观察  

Observation of the effect on transurethral resection of prostate by finasteride in different administrations

作　　者：刘畅 张钦尧 任立红 

机构地区：[1]河南省鹤壁市人民医院(山城院区)泌尿外科,河南鹤壁458000

出　　处：《中国当代医药》2013年第5期87-88,共2页China Modern Medicine

摘　　要：目的探讨非那雄胺以长期常规剂量和短期大剂量两种术前给药方式对经尿道前列腺电切除术(TURP)治疗前列腺增生症(BPH)的影响。方法本研究以确诊的120例中重度前列腺增生患者为处理对象,所有患者随机分成A、B、C3组。A组术前口服非那雄胺3个月,每日1次,每次5mg;B组术前口服非那雄胺5d,每日1次,每次15mg;C组术前未服用任何抗雄激素药物。患者均经同一术者使用OLYMPUSF26电切镜进行TURP术。3组以术中术后出血量、灌洗液量、手术时间和手术野的满意度进行计量比较。结果 A组在术中出血量、术中灌洗液量、手术时间、术中视野的满意度与B、C组相比,差异均有统计学意义(P<0.05),而B、C两组间差异无统计学意义(P>0.05)。A、B组的术后1～3d出血量和冲洗液量与C组相比差异均有统计学意义(P<0.05),而A组与B组间差异无统计学意义(P>0.05)。结论术前长期常规剂量应用非那雄胺可显著减少中重度BPH患者的TURP术中术后出血量。与术前短期大剂量非那雄胺用药相比,长期常规剂量用药明显有益于TURP,值得临床推广应用。Objective To investigate the effect on transurethral resection of prostate （TURP） in treatment of benign prostatic hyperplasia （BPH） by using finasteride with two preoperative administration methods of long-term conven- tional dose and short-term high dose. Methods In this study, 120 patients with confirmed moderately severe BPH were randomly divided into group A, group B and group C. Patients in group A took finasteride 5 mg orally once a day for 3 months before operation, patients in group B took finasteride 15 mg orally once a day for5 days, patients in group C did not take any anti-androgen drugs before operation. All patients underwent TURP by the same operator us- ing the OLYMPUS F26 resectoscope. Intraoperative and postoperative bleeding, lavage fluid volume, operation time and surgical field satisfaction were compared among all groups. Results Group A compared with group B and group C, there were significant differences （P 〈 0.05） between three groups in the intraoperative bleeding volume, lavage fluid volume, operation time and surgical field satisfaction. But there was no significant difference between group B and group C （P〉 0.05）. The bleeding volume 1 to 3 days after operation and lavage fluid volume of group A and group B compared with group C showed statistically significant difference （P 〈 0.05）, but there was no significant difference between group A and group B （P 〉 0.05）. Condusion Using finasteride with long-term conventional dose before oper- ation can significantly reduce the bleeding volume during and after operation of TURP in patients with moderately se- vere BPH. Finasteride with long-term conventional dose is obviously more beneficial to TURP than short-term high dose, so it worthy of clinical application.

关 键 词：非那雄胺 前列腺增生症 经尿道前列腺电切除术 观察 

分 类 号：R697.3[医药卫生—泌尿科学]