我院慢性乙型肝炎患者抗病毒治疗用药分析  

Analysis of usage of anti-HBV drugs in patients with chronic hepatitis B in our hospital

作　　者：王金彩[1] 郑继海[1] 董亭方[1] 

机构地区：[1]新乡医学院第一附属医院药剂科,河南卫辉453100

出　　处：《中国医药导报》2013年第5期124-125,共2页China Medical Herald

基　　金：河南省医学科技攻关计划项目(项目编号:2011020093)

摘　　要：目的了解我院慢性乙型肝炎患者抗病毒治疗的用药情况，为临床合理用药提供参考。方法采用随机抽样与回顾性调查方法，对我院门诊西药房2011年1～12月门诊诊断为慢性乙型肝炎的处方720张，按照药品分类、用药数量、用药频度（DDDs）以及联合用药情况进行统计分析。结果在720张诊断为慢性乙型肝炎的处方中，以抗HBV药物使用为主，其中，核苷类抗病毒药物处方使用率为60．56％。DDDs最高的是阿德福韦酯，抗病毒方案以单独使用抗HBV药为主，占86．01％。结论我院门诊慢性乙型肝炎患者的抗病毒治疗以核苷类药物为主，最常用的抗HBV药物是阿德福韦酯，用药较为合理。Objective To investigate the usage situation of anti-HBV drugs in patients with chronic hepatitis B in our hospital, in order to guide the clinical rational drug use. Methods By random sampling method and retrospective sur- vey, the total 720 chronic hepatitis B prescriptions in pharmacy department of our hospital from January to December 2011 were randomly selected and analyzed statistically, according to the kinds, amounts, DDDs and combination usage of drugs. Results Among 720 chronic hepatitis B prescriptions, the main used drugs were the anti-HBV drugs, the us- age rate of nucleoside antiviral drug was 60.56%, among which DDDs of Adefovir Dipivoxil was ranked the first place. Single use anti-HBV drug was dominant （86.01%） in antiviral scheme. Conclusion Nucleoside/nucleotide analogues are the primary antiviral therapy drugs for patients with chronic hepatitis B in outpatients of our hospital. Adefovir Dipivoxil is the most widely used drug in anti-HBV drugs, which is basically rational used in our hospital.

关 键 词：慢性乙型肝炎 抗HBV药物 DDDS 

分 类 号：R512.62[医药卫生—内科学]