诱骗受体3在HBeAg阴性的慢性乙型肝炎患者中的表达及意义  

Expression and significance of decoy receptor 3 in HBeAg negative chronic hepatitis B patients

作　　者：侯彦强[1] 梁冬雨[1] 彭亮[1] 娄晓丽[1] 刘涛[1] 张鲁榕[2] 

机构地区：[1]上海市松江区中心医院中心实验室,上海201600 [2]美国佛罗里达大学肿瘤研究中心,美国佛罗里达32610

出　　处：《检验医学》2013年第1期37-39,共3页Laboratory Medicine

基　　金：上海市科委科研课题资助项目(12ZR142800)

摘　　要：目的探讨诱骗受体3(DcR3)在乙型肝炎病毒(HBV)e抗原(HBeAg)阴性的慢性乙型肝炎(CHB)患者中的表达及意义。方法采用酶联免疫吸附试验(ELISA)检测80例血清HBeAg阴性的CHB患者和96名正常人血清DcR3;全自动生化分析仪检测丙氨酸氨基转移酶(ALT);聚合酶链反应(PCR)检测HBV DNA。结果 HBeAg阴性的CHB患者血清DcR3水平[1.58(0.48～3.23)ng/mL]明显高于正常对照组[0.83(0.16～2.32)ng/mL,P<0.000 1)]。HBeAg阴性的CHB患者血清DcR3水平与HBV DNA和ALT水平呈正相关(r=0.704、0.732,P均<0.000 1)。结论 DcR3在HBeAg阴性的CHB患者中高表达,并与HBV DNA和ALT强相关,具有潜在的作为HBeAg阴性CHB患者诊断、治疗观测的新指标的应用价值。Objective To investigate the expression and significance of decoy receptor （DcR3） in hepatitis B virus （HBV） e-antigen （I-IBeAg） negative chronic hepatitis B （CHB） patients. Methods Serum DcR3 levels were measured lay enzyme-linked immunosorbent assay （ELISA） in 80 HBeAg negative CHB patients and 96 healthy subjects. Alanine aminotransferase （ALT） was determined by automatic analyzer. Serum HBV DNA was determined by polymerase chain reaction （PCR）. Results DcR3 level in HBeAg negative CHB patients [ 1.58 （0.48-5.23）ng/mL] was significantly higher than that in healthy controls [ 0. 83 （0. 16-2.32） ng/mL, P 〈 0. 000 1 ]. DcR3 level was correlated positively with HBV DNA （ r =0.704, P 〈 0. 000 1 ） and ALT （ r = 0. 732, P 〈 0. 000 1 ）. Conclusions DcR3 has high expression and correlates with HBV DNA and ALT in HBeAg negative CHB patients, and DcR3 may serve as a diagnosis and treatment monitoring indicator for HBeAg negative CHB patients.

关 键 词：诱骗受体3 慢性乙型肝炎 丙氨酸氨基转移酶 DNA 

分 类 号：R446.62[医药卫生—诊断学]