耐甲氧西林金黄色葡萄球菌的临床分布及耐药性分析  

Infectious distribution and drug resistance analysis of Methicillin-resistant Staphylococcus aureus

作　　者：杨长顺[1] 石书凡[1] 

机构地区：[1]湖南省怀化市第一人民医院检验科,418000

出　　处：《检验医学与临床》2013年第3期289-290,共2页Laboratory Medicine and Clinic

摘　　要：目的了解感染耐甲氧西林金黄色葡萄球菌(MRSA)的临床分布及对临床常用抗菌药物的耐药性。方法金黄色葡萄球菌(SA)采用ATB-Expression半自动细菌鉴定仪进行鉴定,采用头孢西丁纸片琼脂扩散法确定MRSA,药敏试验采用K-B纸片扩散法。结果 185株SA中MRSA共计118株(63.78%)。MRSA病区分布以神经外科、肝胆烧伤外科、普外科和呼吸内科为主。118株MRSA对青霉素、氨苄西林、哌拉西林/他唑巴坦、头孢噻肟、美洛培南、环丙沙星、红霉素均耐药;对阿米卡星和利福平耐药率较高;没有发现耐万古霉素和替考拉宁的菌株。结论 MRSA菌株表现为多重耐药性和高耐药性,万古霉素和替考拉林是有效控制MRSA感染的最佳抗菌药物。Objective To understand the infectious distribution of Methicillin-resistant Staphylococcus aureus （MRSA） and its drug resistance to antibiotics. Methods The identification of staphylococcus aureus（SA） was determined by ATB-Expression, MRSA were identified by disk diffusion method with Cefoxitin,and the K-B method was applied for the drug susceptibility test. Results The isolated＇rates of MRSA infection were 63. 780/00 in 185 SA. The infectious distribution of MRSA were mainly in neurosurgery, burn and hepatobiliary surgery,general surgery, respiratory medicine department. 118 strains of MRSA were resistance to penicillin, ampicillin, piperacillin/tazobaetam, cefotaxime, meropenem, ciprofloxaein and erythrocin , and were highly resistance to amikacin and rifampicin. All MRSA were sensitive to vancomycin and teicoplanin. Conclusion MRSA have high and multiple resistant to antimicrobial agents,Vancomycin and teicoplanin were the first drug against MRSA infection.

关 键 词：耐甲氧西林金黄色葡萄球菌 临床分布 耐药性 

分 类 号：R378.11[医药卫生—病原生物学]