脂肪细胞因子基因单核苷酸多态性与2型糖尿病关联性研究进展  

Advances in studies of the association between adipocytokine genes＇ polymorphisms and type 2 dia- betes mellitus

作　　者：刘伟伟[1] 饶绍奇[1] 丁元林[1] 修良昌[1] 孔丹莉[1] 

机构地区：[1]广东医学院流行病与卫生统计学教研室,东莞523808

出　　处：《国际遗传学杂志》2013年第1期18-23,共6页International Journal of Genetics

基　　金：国家自然科学基金（81273166,31071166）;广东省自然科学基金（$2012010008271,2009A030301004）;东莞市科技重点项目（201108101015,2012105102010）;广东医学院建博科技创新团队研究项目（STIF201121,STIF201122）

摘　　要：脂肪细胞因子影响机体对胰岛素的敏感性，导致胰岛素抵抗。其中，肿瘤坏死因子和脂联素两基因多态性与2型糖尿病关联性受到广泛关注。此文对近年来国内外相关研究进行了系统性回顾，发现其多态性与2型糖尿病的关联性在不同人群和种族中存在明显差异。Adipocytokines have influence on the individuals ＇ sensitivity to insulin, leading to in- sulin resistance. The genetic polymorphisms in tumor necrosis factor alpha and adiponeetin, and their asso- ciation with type 2 diabetes mellitus have been widely studied. This article reviewed and summarized the relevant information published in China and internationally in recent years. It has been noted that the asso- ciations between the genetic polymorphisms in these two genes and type 2 diabetes mellitus are markedly different across different populations or races.

关 键 词：脂肪细胞因子 基因多态性 2型糖尿病 肿瘤坏死因子 脂联素 

分 类 号：R587.1[医药卫生—内分泌]