痴呆的中医证型与血浆同型半胱氨酸水平相关性分析  

Study on correlation between plasma homocysteine levels and TCM syndromes ofdementia

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作  者:徐新春[1] 张慧[1] 林梅[1] 陈雷[1] 

机构地区:[1]上海市徐汇区中心医院中医科,200031

出  处:《国际中医中药杂志》2013年第2期104-105,共2页International Journal of Traditional Chinese Medicine

基  金:上海市徐汇区卫生局科研基金资助项目(项目编号:SHXH20060421)

摘  要:目的了解痴呆患者的中医证型与血浆同型半胱氨酸(Hcy)水平的关系。方法将病例资料分为痴呆组(120例)、非痴呆组(130例),比较两组患者血浆Hcy水平,同时对痴呆患者进行中医辨证,对不同证型患者的Hcy水平进行比较。结果痴呆患者血浆Hcy(17.13±9.01)nmol/ml明显高于非痴呆者(12.81±7.94)nmo1/ml:痰浊阻窍者血浆Hcy水平(18.43±7.81)noml/ml明显高于其他5型[瘀阻脑络(5.38±8.91)nmol/ml、肾虚髓亏(16.44±9.05)nmol/ml、肾阴亏虚(16.19±9.24)nmol/ml、肝经火旺(15.92±7.28)nmol/ml、脾肾阳虚(12.26±5.17)nmol/ml,P〈0.01]。结论高Hcy可能是痴呆发病的高危险因素之一。Objective To investigate the relationship between plasma homocysteine (Hcy) levels and TCM syndromes of dementia. Methods 250 cases were divided into a dementia group (120 cases) and non-dementia group (130 cases). 120 cases in the dementia group include 36 Alzheimer dementia(AD) patients and 84 vascular dementia (VaD) patients. The plasma levels of Hcy were measured in all 250 cases. The relationship between Hcy levels, TCM syndromes and dementia was analyzed. Results The level of plasma Hcy was significantly higher in the dementia group (17.13 ± 9.01) nmol/ml than that in the non-dementia group (12.81 ±7.94) nmol/ml, and it was highest in the VaD patients (P〈0.01). The mean of Hey concentration in obstruction of phlem-turbid syndrome was higher (18.43 ±7.81) nmol/ml than syndromes [Tanyuzuluo (5.38 ±8.91)nmol/ml, Shenxusuikul (16.J14 ± 9.05)nmol/ml, Shenyinkuixu (16.19 ± 9.24)nmol/ml, Ganjinghuowang (15.92 ± 7.28) nrnol/ml, Pishen-Yangxu (12.26 ± 5.17) nmol/ml (P 〈 0.01) ]. Conclusion Increased plasma Hcy levels may be one of the risk factors leading to AD or VaD.

关 键 词:痴呆 同型半胱氨酸 中医证型 

分 类 号:R259[医药卫生—中西医结合]

 

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