压力性溃疡中药组方影响大鼠微循环作用探讨  

Effects of traditional Chinese treating pressure ulcer compound on microcirculation in rats

作　　者：张建国[1] 杨光[1] 石炳娟 李丽[1] 周建民[1] 

机构地区：[1]山东省高密市人民医院,261500 [2]山东省潍坊市药品检验所,251041

出　　处：《国际中医中药杂志》2013年第2期129-132,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的观察压力性溃疡中药组方对大鼠微循环的影响。方法大鼠采用随机数字表法分为中药组方高剂量组、中药组方低剂量组、阳性对照组和阴性对照组。肠系膜局部滴加肾上腺素液造成大鼠肠系膜微循环障碍模型，考察各组受试大鼠的细动脉管径、细动脉流速、毛细血管网交点计数等指标。结果各时段大鼠肠系膜细动脉管径变化，阳性对照组分别为（74．73±4．23）min、（73．46±4．02）min、（81．60±3．23）min、（93．37±3．84）min、（98．38±3．25）min，中药组方高剂量组分别为（72．26±2．90）min、（72．16±3．20）min、（82．45±2．85）min、（94．64±3．37）min，两组比较无显著性差异p〉0．05）。各时段大鼠肠系膜细动脉流速变化，阴性对照组分别为（5．06±1．12）min、（3．47±0．97）min、（8．51±1．15）rain、（43．55±3．24）min、（56．47±3．54）min，阳性对照组分别为（19．37±1．81）min、（21．54±2．69）rain、（39．86±3．53）min、（86．41±4．27）min、（94．35±4．23）min，中药组方高剂量组分别为（13．73±2．oz）min、（22．67±2．48）min、（46．32±4．27）min、（89．18±5．13）min、（95．07±4．67）min，中药组方低剂量组分别为（6．22±1．48）min、（10．34±2．09）min、（25．41±2．49）min、（56．87±3．75）min、（74．30±3．18）min，阳性对照组和中药组方高剂量组大鼠肠系膜细动脉流速9min均恢复到滴加肾上腺素前水平（P〉0．05），阳性对照组、中药组方高剂量组与中药组方低剂量组、阴性对照组各时段数据比较有显著差异泸〈0．05）。各时段大鼠肠系膜毛细血管网交点计数变化，阴性对照组分别为0、16．92±1．17、39．19±2．65，阳性对照组分别为20．66±1．89、36．78±3．04、76．04±4．29，中药组方高剂量组分别为14．33±1．46、43．75±3．74、81．23±3．34，Objective To observe the effect of traditional Chinese treating pressure ulcer compound on microcirculation of rats in-vivo. Methods Rats were divided into four groups according to the random number table, includeing high-dose group, low-dose group, positive control group and negative control group. Model rats of microcirculation disturbance were created by dropping epinephrine on partial of mesentery, and then the following indexes of four groups were detected： arteriole diameter, arteriole flow rate, junction of capillary network counts, etc. ResuRs The rats mesentery arteriole diameter variation of positive control group in different time were （74.73 ± 4.23） min, （73.46 ± 4.02） min, （81.60± 3.23） min, （93.37± 3.84） min, （98.38 4± 3.25）min respectively, and the variation of high-dose group in different time were （72.26±2.90） min, （72.16_ 3.20） min, （82.45±2.85） min, （94.64± 3.37）min respectively. There was no significant difference between the two groups （P〉O.05）. The rats mesentery arteriole flow rate variation of negative control group in different time were （5.06±1.12）min, （3.47±0.97）min, （8.51±1.15）min, （43.55 ±3.24） min, （56.47±3.54）min respectively, the variation of positive control group were （19.37± 1.81）min, （21.54±2.69） min, （39.86±3.53）rain, （86.41±4.27） min, （94.35±4.23） min respectively, the variation of high-dose group were （13.73± 2.02） min, （22.67± 2.48） min, （46.32 ±4.27） min, （89.18 ± 5.13） min, （95.07 ± 4.67） min respectively, and the variation of low-dose group were （6.22±1.48）min, （10.34±2.09）min, （25.41±2.49）min, （56.87±3.75）min, （74.30±3.18）min respectively. The rats mesentery arteriole flow rate has recovered to the level of before dropping epinephrine by 9 min in positive control group and high-dose group, and there were no significant difference between the two groups （P〉0.05）, but there were statistical significance when high-dos

关 键 词：中药组方 微循环 药理作用 压力性溃疡 

分 类 号：R28[医药卫生—中药学]