葛根素-羟丙基-β-环糊精包合物的制备及其性质表征  

Preparation and properties of puerarin-hydroxypropyl-β-cyclodextrin inclusion compound

作　　者：张娥[1] 谭睿[2] 顾健[1] 何黎黎[1] 姚峰[1] 

机构地区：[1]西南民族大学民族医药研究院,四川成都610041 [2]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《华西药学杂志》2013年第1期23-25,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:81173594);中央高校基本科研业务费专项资金项目(编号:11NZYTH02);四川省应用基础项目(编号:2012JY0025);四川省科技支撑项目(编号:2011SZ0231);成都市科技局项目(编号:11DXYB263JH-027)

摘　　要：目的制备葛根素-羟丙基-β-环糊精包合物,并研究其性质表征,计算包合过程的热力学常数。方法采用饱和水溶液-超声法制备包合物,然后使用X射线衍射法、红外光谱法鉴定包合物,并通过表观溶解度法测定包合过程中各热力学常数。结果成功制备了葛根素-羟丙基-β-环糊精包合物,葛根素与羟丙基-β-环糊精摩尔比为1∶1,相溶解度图呈AL型。结论羟丙基-β-环糊精作为包合材料,能显著增大葛根素的溶解度,为后期的渗透泵片的研究奠定了基础。OBJECTIVE To prepare the puerarin-hydroxypropyl-β-cyclodextrin inclusion compound（Pu-HP-β-CD） and investigate the properties and thermodynamic constants of inclusion.METHODS Pu-HP-β-CD was prepared by the saturation aqueous solution-ultrasonic method.Then,inclusion compound was identified by X ray iffraction（XRD） and infrared spectrometry（IR） method.The thermodynamic constants were also calculated by phase solubility method.RESULTS Pu-HP-β-CD was prepared successfully and the molar ratio of host and guest molecular was 1：1.The phase diagram was AL type.CONCLUSION The solubility of puerarin included by hydroxypropyl-β-cyclodextrin is increased obviously,which also establish the foundation for further study on the osmotic pump tablets of puerarin.

关 键 词：葛根素 羟丙基-Β-环糊精 包合物 性质表征 饱和水溶液超声法 X射线衍射法 红外光谱法 

分 类 号：R94[医药卫生—药剂学]