玉郎伞提取物对高脂血症大鼠血液流变学的影响  

Effects of Yulangsan extracts on hemorheology in hyperlipidemic rats

作　　者：陈丽[1,2] 张士军[1] 黄建春[1] 陈兆霓[1] 黄仁彬[1] 

机构地区：[1]广西医科大学药理教研室,广西南宁530021 [2]柳州医学高等专科学校药学教研室,广西柳州545005

出　　处：《华西药学杂志》2013年第1期41-44,共4页West China Journal of Pharmaceutical Sciences

基　　金：广西科学研究与技术开发计划项目(No.0630002-2A)

摘　　要：目的研究玉郎伞(YLS)块根提取物(总黄酮、多糖及其水提物)对食饵性高脂血症大鼠脂质代谢及血液流变学指标的影响。方法建立食饵性高脂血症大鼠模型,将YLS提取物给予高脂血症大鼠,连续灌胃14 d后,检测各组大鼠脂质水平及全血黏度(WBV)、血浆黏度(PV)、全血还原黏度(RV)、红细胞压积(HCT)等8项血流变学指标。结果与高脂模型组比较,各用药组TC、TG、LDL-C、apoB、AI水平降低;apoA1、HDL-C、apoA1/apoB水平显著性升高(P<0.01或P<0.05);各给药组8项血液流变学指标显著降低(P<0.01或P<0.05),YLS总黄酮高、低剂量组效果最明显。结论 YLS提取物对高脂血症大鼠的脂质代谢紊乱有显著的调节作用,对防治高脂血症和改善血液流变学有积极的意义。OBJECTIVE To explore the effects of the extracts（flavonoid,polysaccharide and water extract） from Yulangsan（YLS） on the blood lipids and the hemorheology in hyperlipidemic rats induced by high lipid diet.METHODS Healthy SD rats were raised by high lipid diet to establish the hyperlipidemic rat model.Serum lipoprotein levels and haemorheology（included WBV,PV,RV,HCT,TK,IR,RE,Fib） were tested after treatment of the hyperlipidemic rats with corresponding drugs once per day for 14 consecutive days.RESULTS Compared with the model group,the levels of the serum TC,TG,LDL-C,apoB and AI were decreased significantly,while that of apoA1,HDL-C and apoA1/apoB were increased significantly（P0.05 or P0.01） in all treated groups.And the 8 indexes of hemorheology all decreased significantly（P0.05 or P0.01）.High and low dose groups of YLS flavonoids especially had the most obvious improving effects.CONCLUSION The lipid metabolic disorder and hemorheology abnormality of hyperlipidemic rats are improved significantly by the treatment with YLS extracts which have positive significance in the hyperlipidemia treatment.

关 键 词：玉郎伞 提取物 高脂血症大鼠 脂质代谢 血液流变学 

分 类 号：R96[医药卫生—药理学]