芍药苷作用于神经系统的研究进展  

Advance in studies on effect of paeoniflorin on nervous system

作　　者：胡增峣[1] 徐岚[1] 闫蓉[1] 黄晏[1] 刘港[1] 周文霞[1] 张永祥[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国中药杂志》2013年第3期297-301,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2012ZX09301003-002;2012ZX09J12201-002;2011ZXJ09201-011);国家自然科学基金青年基金项目(81100239)

摘　　要：芍药苷是芍药的主要活性成分,药理作用多样,应用广泛。近来,芍药苷对神经系统的作用研究受到越来越多的关注。目前的研究结果认为,芍药苷对多种痴呆模型动物的学习记忆功能衰退有改善作用,对脑缺血损伤有明显的保护作用,对帕金森病有一定的治疗作用,还具有镇痛、改善神经突触可塑性损伤等作用。其作用机制尚未完全阐明,现有结果显示腺苷A1受体在其中发挥了较为重要的作用,M胆碱受体、阿片受体、Ca2+通道、NF-κB等也都可能参与了芍药苷对神经系统的作用。Paeoniflorin （PF） is the chief active component of paeonia, with diverse pharmacological actions and wide applica- tion. Recently, the effect of PF on nervous system has attracted increasingly more attention. According to current study findings, PF can ameliorate the decline of memory and learning capacities in many dementia model animals, and have effect in protecting the cere- bral ischemia injury, treating Parkinson＇s disease, reliving pain and improving neural synapse plasticity. Thought its mechanism has not been clarified, current findings show that adenosine A1 receptor plays an important role, while M cholinergic receptor, opiate re- ceptor, calcium ion channel and NF-KB may also play a part in paeoniflorin＇s effect on nervous system.

关 键 词：芍药苷 神经退行性疾病 脑缺血 腺苷A1受体 芍药内酯苷 

分 类 号：R285[医药卫生—中药学]