以羟基磷灰石为载体的穿心莲内酯固体分散体研究  

Study on andrographolide solid dispersion vectored by hydroxyapatite

作　　者：胡绍英[1,2] 张振海[1] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学,江苏南京210046

出　　处：《中国中药杂志》2013年第3期341-345,共5页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局中药释药系统重点研究室开放基金项目(2011NDDCM01002);江苏省高等学校大学生创新训练计划项目(011042004000)

摘　　要：目的:以羟基磷灰石为载体制备穿心莲内酯固体分散体,提高药物溶出度。方法:将穿心莲内酯和羟基磷灰石分散于95%乙醇中,采用溶剂蒸发法制备穿心莲内酯固体分散体,对其溶出行为、稳定性、物相特征进行研究。结果:穿心莲内酯和羟基磷灰石按1∶8制备的固体分散体,经差示扫描量热、X衍射、电镜分析,固体分散体中药物以非晶形式存在于载体中,45 min时药物的体外累积溶出度达到93%;经过3个月稳定性加速试验后,固体分散体中药物溶出度和含量均未发生明显变化。结论:以羟基磷灰石为载体制备的固体分散体能有效提高难溶性药物穿心莲内酯的溶出度和稳定性。Objective： To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution. Method： Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopt- ed to prepare andrographolide solid dispersion, in order to study its dissolution behavior, stability and physical characteristics. Result： The solid dispersion prepared with andrographolide and hydroxyapatite with the proportion of 1：8 existed in the vector in an amorphous form, according to differential scanning calorimetE~, scanning electron microscopy and X-ray powder diffraction. The in vitro dissolution of andrographolide solid dispersions was up to 93% at 45 min. After the accelerated stability test for three months, the drug dissolution and content in andrographolide solid dispersion showed no significant change. Conclusion： The prepared solid dispersions with hydroxyapatite as the vector can effectively improve the stability and dissolution of water-insoluble drug andrographolide.

关 键 词：穿心莲内酯 羟基磷灰石 固体分散体 溶出度 稳定性 

分 类 号：R283[医药卫生—中药学]