湖南省2011年艾滋病患者抗病毒治疗及时性分析  

Summary of anti-HIV treatment of AIDS patients in Hunan province of China during 2011

作　　者：魏秀青[1] 张园园[1] 陈曦[1] 贺健梅[1] 张国强[1] 李向忠[1] 

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410005

出　　处：《中国病毒病杂志》2013年第1期42-45,共4页Chinese Journal of Viral Diseases

基　　金：中国全球基金艾滋病项目(CHN-304-G03-H)

摘　　要：目的分析湖南省2011年艾滋病抗病毒治疗的情况,了解该省艾滋病患者治疗的现状及存在的问题。方法从国家艾滋病综合防治信息系统中导出湖南省患者治疗数据,用SPSS 17.0统计软件进行分析处理,了解患者在接受治疗时的WHO分期、基线CD4+T淋巴细胞水平、治疗与确证时间间隔及相关临床症状与疾病。结果 2011年共有1 474例成人病例纳入治疗,平均年龄(42.0±13.1)岁,66.1%(975例)是男性,感染途径以性传播为主(81.5%,1 202例);接受治疗时,38.5%(568例)的患者处于WHO临床Ⅰ期(无症状期),24.6%(362例)的患者处于临床Ⅱ期(轻度疾病期),24.2%(357例)的患者处于临床Ⅲ期(中度疾病期),12.7%(187例)的患者处于临床Ⅳ期(严重疾病期);基线CD4+T淋巴细胞平均166个/μl,<50个/μl、51～200个/μl、201～350个/μl及>350个/μl的分别占22.7%、37.5%、37.1%和2.7%;74.3%的基线CD4+T淋巴细胞计数低于200个/μl的患者能在确证诊断后6个月内接受治疗,治疗与确证诊断间隔中位数为70d;接受治疗前的1年有175例(11.9%)发生结核感染,563例(38.2%)在治疗前3个月内出现1种以上的症状和疾病,较常见的是发热(17.1%)、皮肤损害(9.1%)和鹅口疮(7.1%)。结论患者接受抗病毒治疗前CD4水平较低,部分已进入疾病期,需要进一步加强早期检测,使更多患者能够在疾病早期得到确诊并及时纳入治疗。Objective To analyze the results of current treatment and challenges of the government-funded free anti-HIV therapy for AIDS patients at different clinical stages in Hunan province of China.Methods Data were obtained from the National Comprehensive Prevention and Treatment Database and analyzed using SPSS 17.0.The variables included WHO clinical staging information,baseline CD4＋ T lymphocyte count（CD4＋ count）,time interval from diagnosis to treatment,clinical symptoms and signs.Results A total of 1 474 AIDS patients in Hunan province of China were enrolled in the anti-HIV program during 2011 with the mean age at 42.0±13.1 years old;66.1% were males.81.5% of the patients acquired their HIV infection through sexual contact.38.5% of the patients were at WHO clinical stage Ⅰ（asymptomatic period）,24.6% in clinical stage Ⅱ（mild disease period）,24.2% in clinical stage Ⅲ（moderate disease period）,12.7% were severe cases（AIDS period）.The average of baseline CD4＋ count was 166/μl;The percentages of patients with their baseline CD4＋ counts at50/μl,51-200/μl,201-350/μl and 350/μl are 22.7%,37.5%,37.1% and 2.7%,respectively.74.3% patients with the baseline CD4＋ count below 200/μl received treatment within 6 months after the confirmatory diagnosis;the median interval between the confirmatory diagnosis and the treatment was 70 days.Tuberculosis infection was reported in 175 cases（11.9%） one year prior to the treatment;combined symptoms and diseases such as fever（17.1%）,skin lesion（9.1%） and thrush（7.1%）were reported in 563 cases（38.2%）3 months prior to treatment.Conclusions Most patients showed low CD4＋ count or have already at the late clinical stage before they were enrolled in the anti-HIV treatment program and therefore,more efforts are needed to ensure diagnosis and treatment in a timely manner.

关 键 词：艾滋病 CD4+T淋巴细胞计数 机会感染 

分 类 号：R512.91[医药卫生—内科学]