心室钾通道电流对室性心律失常的影响及调控  

Effect of Ventricular Potassium Current on Ventricular Arrhythmia and Regulation

作　　者：高飞[1] 张季谦[1,2] 蒋迎芳[1] 程睿[1] 

机构地区：[1]安徽师范大学物理与电子信息学院,安徽芜湖241000 [2]曼彻斯特大学物理与天文系生物物理中心

出　　处：《生物物理学报》2013年第1期64-72,共9页Acta Biophysica Sinica

基　　金：国家自然科学基金理论物理专款项目(11047017);安徽省自然科学基金项目(090413099)~~

摘　　要：本文采用犬心室外膜细胞模型,仿真模拟了不同剂量药物阻滞钾通道电流(iKr和iKs)对室性心律失常产生的影响及调控作用。结果发现,适当阻滞钾电流可减轻室性心律失常,甚至使心律恢复正常。然而,若药物剂量使用过大,过度阻滞钾电流,则会引起早期后除极(earlyafterdepolarization,EAD)的产生,导致室性心律失常症状的加重。此时,我们可以通过调节细胞外钠离子浓度([Na+]o)和晚钠电流(iNaL)等方法来减轻或消除这种负面影响。In this paper,by using the canine ventricular epicardial cells model,the authors simulated the effects of blocking potassium current（iKr and iKs） with different dose drug on ventricular arrhythmias and its regulation.The results show that the ventricular arrhythmia could be reduced by blocking potassium current appropriately,and it could even return to the normal level.However,if the drug doses were used heavily,it might block potassium current overly,and this would result in the early after depolarization（early after-depolarization,EAD）,it would increase the symptomatic of ventricular arrhythmia.To address this,we could reduce or eliminate those negative effects mentioned above by regulation of extracellular sodium concentration（[Na＋]o） and the late sodium current（iNaL）,as well as other methods.

关 键 词：室性心律失常 钾通道电流 早期后除极 仿真模拟 

分 类 号：Q463[生物学—生理学]