龙甲血脉通胶囊对大鼠心肌缺血及心肌缺血再灌注损伤的保护作用  

Protection of Longjia Xuemaitong Capslue on myocardial ischemia and myocardial ischemia-reperfusion injury in rats

作　　者：王玉姝[1] 李欢[2] 宋东伟[1] 张腾[1] 周晓棉[3] 

机构地区：[1]天津生物工程职业技术学院,天津300462 [2]齐齐哈尔大学,黑龙江齐齐哈尔161006 [3]沈阳药科大学,辽宁沈阳110016

出　　处：《现代药物与临床》2013年第1期25-28,共4页Drugs & Clinic

摘　　要：目的探讨龙甲血脉通胶囊对大鼠心肌缺血及心肌缺血再灌注损伤的保护作用。方法采用垂体后叶素和异丙肾上腺素诱导的大鼠心肌缺血模型,考察龙甲血脉通胶囊对心肌缺血作用的保护;采用手术致大鼠心肌缺血再灌注损伤模型,考察龙甲血脉通胶囊的对心肌缺血再灌注损伤的保护作用。结果龙甲血脉通胶囊(1.60、0.80、0.40g/kg)能够显著降低垂体后叶素诱导的心肌缺血大鼠15s、30s时T波高度;能够显著降低异丙肾上腺素诱导的大鼠心肌缺血5、10、20、30minS-T段偏移高度。龙甲血脉通胶囊(1.60、0.80、0.40g/kg)能够显著降低血清丙二醛(MDA)水平,显著升高超氧化物歧化酶(SOD)水平,显著降低缺血再灌注损伤大鼠的心肌梗死区面积占缺血区面积的比例。结论龙甲血脉通胶囊具有保护心肌缺血及抗心肌缺血再灌注损伤的作用。Objective To observe protective effects of Longjia Xuemaitong Capslue on myocardial ischemia and cardiac reperfusion injury.Methods Using the myocardial ischemia model of rats induced by pituitrin and isoproterenol,the effects of Longjia Xuemaitong Capslue on myocardial ischemia were investigated.Moreover,using the myocardial ischemia-eperfusion injury model of rats induced by operation,the protective effects of Longjia Xuemaitong Capslue on myocardial ischemia-reperfusion injury were observed.Results At the doses of 1.60,0.80,0.40 g/kg,Longjia Xuemaitong Capslue could significantly reduce the T wave height at 15 and 30 s in the ischemia rats induced by pituitrin as well as the offset height of S-T segment at 5,10,20,and 30 min in ischemia rats induced by isoproterenol.Longjia Xuemaitong Capslue at the doses of 1.60,0.80,and 0.40g/kg could significantly decrease the malondialdehyde （MDA） level in serum,increase the superoxide dismutase （SOD） level,and obviously decrease the percentage that the infarct area accounted for the ischemic area in the myocardial ischemia-reperfusion injury of rats.Conclusion Longjia Xuemaitong Capslue could protect the myocardial ischemia and myocardial ischemia-reperfusion injury.

关 键 词：龙甲血脉通胶囊 心肌缺血 心肌缺血再灌注损伤 垂体后叶素 异丙肾上腺素 血清丙二醛 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]