Synthesis and Antitussive Effect of New Hydantoin Compounds  

作　　者：ZHANG Qun-li SONG Li-jun WANG En-si 

机构地区：[1]College of Life Science, [2]The First Hospital, [3]College of Pharmacy, Jilin University, Changchun 130021, P. R. China

出　　处：《Chemical Research in Chinese Universities》2013年第1期76-81,共6页高等学校化学研究（英文版）

摘　　要：A series of new hydantoin compounds was synthesized with 3-bromo phenylacetic acid and 3,4-dimethylbromobenzene as starting material, 7-bromo-2-tetralone and 2-bromo-5,6,8,9-tetrahydro-7-benzocycloheptenone as intermediate and Ullmann reaction, Suzuki reaction and Bucherer-Berg＇s reaction as key steps. The structures of the key intermediate and target compounds were confirmed by lH NMR, 13C NMR, IR and MS. Bioactivity research showed that target compounds 6a, 6c, 6d, 6e and 15i had significant antitussive effect on the ammonia-induced couch of mice.A series of new hydantoin compounds was synthesized with 3-bromo phenylacetic acid and 3,4-dimethylbromobenzene as starting material, 7-bromo-2-tetralone and 2-bromo-5,6,8,9-tetrahydro-7-benzocycloheptenone as intermediate and Ullmann reaction, Suzuki reaction and Bucherer-Berg＇s reaction as key steps. The structures of the key intermediate and target compounds were confirmed by lH NMR, 13C NMR, IR and MS. Bioactivity research showed that target compounds 6a, 6c, 6d, 6e and 15i had significant antitussive effect on the ammonia-induced couch of mice.

关 键 词：HYDANTOIN 2-Bromo-5 6 8 9-tetrahydro-7-benzocycloheptenone Bioactivity 7-Bromo-2-tetralone Anti-tussive effect 

分 类 号：TQ463[化学工程—制药化工] TQ463.4