Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative  

出　　处：《Science China(Physics,Mechanics & Astronomy)》2013年第3期321-328,共8页中国科学：物理学、力学、天文学（英文版）

摘　　要：The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess （up to 99%）.

关 键 词：Cinchona alkaloid-based thiourea Mannich reaction p-amino esters enantioselective synthesis 

分 类 号：O645.4[理学—物理化学] O625.42[理学—化学]