亚麻木酚素提取物对糖尿病大鼠肾脏足细胞的影响  

Effect of flaxseed lignan extract on podocytes in diabetic nephropathy rats

作　　者：徐海娥[1] 张慧[1] 王孙璟[1] 顾呈华[2] 李莉[2] 

机构地区：[1]南京医科大学第二附属医院营养科,南京210011 [2]江苏省疾病预防控制中心,南京210019

出　　处：《中国卫生检验杂志》2013年第1期84-86,共3页Chinese Journal of Health Laboratory Technology

基　　金：南京医科大学科技发展基金面上项目(2010Njmu080)

摘　　要：目的:观察亚麻木酚素提取物对糖尿病大鼠肾脏足细胞损伤的影响。方法:将未造模大鼠作为正常对照组;成模大鼠随机分为3组(模型组、实验组、药物对照组)。实验12周末检测24 h尿白蛋白排泄率、肾重系数等变化,透射电镜观察肾脏足细胞超微病理结构变化。结果:与糖尿病模型组比较,实验组降低肾重、24 h尿白蛋白排泄率、Scr、BUN(P<0.05)。实验组和药物对照组病理改变均较糖尿病模型组明显减轻,足突部分融合,系膜基质轻度增多,肾小球基底膜增厚减轻。结论:亚麻木酚素提取物可减轻糖尿病大鼠肾脏足细胞病理损伤,改善肾功能。Objective：To explore the effect of Flaxseed Lignan Extract on the podocytes of rats with diabetes nephropathy.Methods： Fifty Wistar rats were randomly divided into normal control group,DN model group（model group）,Enalapril treatment group,Flaxseed Lignan Extract treatment group.After 12 weeks,24 h urinary protein excretion rate,BUN,Scr and kidney weight/body weight were determined.The renal pathology and the changes of podocytes were observed under light microscope and transmission electron microscope.Results： After treatment of Flaxseed Lignan Extract and Enalapril,urinary protein quantity in 24 h,SCr,BUN were reduced（respectively P0.05） compared with the DN model group.Flaxseed Lignan Extract and Enalapril can improve ultrastructure in kidney of diabetic rats,lessen the fusion of foot process,ameliorate the renal pathomorphology change.Conclusion： Flaxseed Lignan Extract can rescue the podocyte injury and provide protective effects on renal fuction of diabetic nephropathy rats.

关 键 词：木酚素 开环异落叶松脂素 糖尿病肾病 足细胞 

分 类 号：R587.1[医药卫生—内分泌]