病理性瘢痕与TGF-β介导的信号通路的相关性研究进展  

Progress on correlated research between pathological scar and signal pathway mediated by TGF-β

作　　者：徐孝兴[1] 梁杰[2] 

机构地区：[1]广东医学院,湛江524023 [2]广东医学院附属医院整形外科,湛江524001

出　　处：《齐齐哈尔医学院学报》2013年第1期77-80,共4页Journal of Qiqihar Medical University

摘　　要：病理性瘢痕是对创伤产生的异常反应,可导致明显的形态和功能障碍。由于其发病机制尚未明确,成为目前困扰临床治疗日益突出的问题。随着细胞学、分子生物学等学科的发展,近年来研究不再局限于某一物质,而是将相关物质联系起来。信号通路蛋白导致瘢痕疙瘩形成的机制研究就是当前的一个热点。本文就其中转化生长因子β1(TGF-β1)介导的信号通路做一综述。The pathological scar is an abnormal reaction to the trauma, which can lead to apparent obstacle of morphology and function. It is not yet very clear that how the scar is formed. The scar is a big problem which makes clinicians puzzled. With the development of discipline such as cytology, molecular biology, studying in recent years is no longer confined to some one matter, but is that relevant matter is contacted. The research of the mechanism shows that how signal transduction protein leads to the formation of the scar is a current hot spot. A review about the signal pathway mediated by transforming growth factor - β （TGF - β） will be done in this paper.

关 键 词：病理性瘢痕 信号通路 转化生长因子Β 

分 类 号：R619.6[医药卫生—外科学]