注射用硫酸头孢噻利与三种输液配伍的稳定性观察  

Observation about compatible stability of cefoselis sulfate mixed injection with different kinds of transfusions

作　　者：王笑蓉[1] 李铭铭[1] 吴明钗[1] 

机构地区：[1]瑞安市人民医院药剂科,浙江省瑞安325200

出　　处：《中国基层医药》2013年第2期217-219,I0003,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察注射用硫酸头孢噻利与三种输液的配伍稳定性，为临床合理配伍使用提供依据。方法在30℃下，将注射用硫酸头孢噻利分别与5％果糖注射液、果糖氯化钠注射液和转化糖注射液配伍，在6h内观察配伍液的外观、pH值变化，并采用高效液相色谱法测定三种配伍液中注射用硫酸头孢噻利的含量。结果注射用硫酸头孢噻利与三种输液在6h内含量、pH值及外观均无明显变化。结论注射用硫酸头孢噻利与三种输液在30℃，6h内配伍稳定。Objective To investigate the compatible stability of cefoselis sulfate mixed with different kinds of transfusions（5% fructose injection ＋ cefoselis sulfate,fructose sodium chloride injection ＋ cefoselis sufate and invert sugar injection ＋ cefoselis sulfate）. Methods At 30℃, the above different mixed solutions＇ appearance and pH changes within six hours were observed, and determine the concentration of cefoselis sulfate by HPLC. Results There were noobvious changes concern to the concentration, pH and appearance in the mixed solutions. Conclusion At 30℃, different cefoselis sulfate mixed injection all have good compatible stability within 6 hours.

关 键 词：头孢噻利 输液 配伍 高效液相色谱法 稳定性 

分 类 号：R9[医药卫生—药学]