降钙素原在重型颅脑损伤患者医院感染早期诊断中的应用  

The application of serum procalcition in early diagnosis of nosocomial infection in severe cerebral injury

作　　者：袁慧峰[1] 赵红星[1] 

机构地区：[1]合肥市第一人民医院重症医学科,安徽省合肥230000

出　　处：《中国基层医药》2013年第2期237-239,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨降钙素原（PCT）在重型颅脑损伤患者医院感染早期诊断中的临床应用价值。方法纳入因重型颅脑损伤人住ICU患者58例，在入住ICU时及入住第3天时检测PCT、C反应蛋白水平及白细胞计数，监测医院感染发生情况。结果两组入住ICU时血清PCT水平差异无统计学意义（P〉0．05），入住ICU第3天时感染组血清PCT水平明显升高，与非感染组差异有统计学意义（t=5．44，P〈0．01）；两组问C反应蛋白、白细胞计数在人住ICU时及人住ICU第3天时差异均无统计学意义（均P〉0．05）。结论降钙素原测定有助于早期诊断急性颅脑疾病患者医院感染，早期合理选用抗生素，减少细菌耐药性的发生，可降低病死率。Objective To investigate clinical value of serum procalcition（PCT） in early diagnosis of nosocomial infection in severe cerebral injury. Methods 58 patients with severe cerebral injury needing ICU monitoring were enrolled. Levels of serum PCT and C-reactive protein（CRP） and white blood cell（WBC） and nosocomial infection when entering ICU or on days 3 were observed. Results There were not difference in level Serum PCT when entering ICU in infection group compared with non-infection group（P 〉 0.05）. Serum PCT increeassd remarkably when entering ICU on days 3 in infection group as compared with non-infection group, the difference was significant （t = 5.44 ,P 〈 0. 01 ）. There were not difference in CRP and WBC level when entering ICU or on days 3 （ all P 〉 0.05 ）. Conclusion Detection of serum PCT helps diagnosis early nosocomial infection in patients with severe cerebral injury. It is suggested that antibiotics should be chosen early in patients with obviously increased PCT, control abuse of an- tibiotics contributes to reduce incidence of drug resistance and mortality.

关 键 词：降钙素原 医院感染 C反应蛋白 白细胞 

分 类 号：R651[医药卫生—外科学]