血清甘胆酸、促甲状腺激素、甲状腺过氧化物酶抗体和总胆汁酸检测在妊娠期肝内胆汁淤积症的临床意义及优生意义  

Clinical significance of serum Cholyglycine,thyroid stimulating hormone,Thyroid peroxidase antibodies and total bile acid detection in intrahepatie eholestasis of pregnancy and meaning of birthy Health

作　　者：周黎[1] 陈捷[1] 吴坚敏[1] 

机构地区：[1]浙江省宁波大学附属阳明医院,余姚市人民医院,检验科

出　　处：《中国优生与遗传杂志》2013年第2期61-62,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血清甘胆酸(CG)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、总胆汁酸(TBA)测定对妊娠期肝内胆汁淤积症(ICP)的诊断价值及优生意义,并与正常妊娠妇女进行比较。方法分别测定74例妊娠期肝内胆汁淤积症(ICP)和136例正常对照组血清甘胆酸、促甲状腺激素、甲状腺过氧化物酶抗体和总胆汁酸检测。观察CG、TSH、TPOAb、TBA与妊娠期肝内胆汁淤积症的关系。结果与正常妊娠妇女比较,ICP孕妇血清CG、TSH、TPOAb、TBA明显升高。结论血清CG是目前诊断ICP敏感的血清学指标之一,对ICP的诊断有重要意义。ICP妇女甲状腺功能存在异常,可能参与了ICP的发生及发展。TBA与ICP的相关性显著,可将TBA作为ICP的主要检测指标。Objective：To investigative the Diagnostic value of detection of serum Cholyglycine,thyroid stimulating hormone,Thyroid peroxidase antibodies and total bile acid in intrahepatic cholestasis of pregnancy（ICP）and meaning of eugenics,and compared with those in normal pregnant women.Methods： Serum Cholyglycine,thyroid stimulating hormone,Thyroid peroxidase antibodies and total bile acid were determined in 74 patients with intrahepatie eholestasis of pregnancy（ICP） and 136 cases of normal pregnant women respectively.To observe CG,TSH,TPOAb,TBA relationship with intrahepatie eholestasis of pregnancy.Results： Compared with those in normal pregnant women,Results showed that serum CG,TSH,TPOAb and TBA increased significantly,was observed in women with ICP.Conclusions： Serum CG is current diagnosis ICP sensitive serological indexes.The diagnosis of ICP has important significance.ICP women,abnormal thyroid function,may be involved in the occurrence and development of ICP.TBA and ICP correlated significantly,TBA can be detected as the main indicators of ICP.

关 键 词：妊娠期肝内胆汁淤积症 甘胆酸 促甲状腺激素 甲状腺过氧化物酶抗体 总胆汁酸 优生意义 

分 类 号：R714.25[医药卫生—妇产科学]