人类姊妹胚胎体外囊胚形成情况与妊娠结局关系的研究  

Explore the relationship between the developmental potential of human surplus embryos during IVF-ET cycles and the pregnancy outcome

作　　者：胡煜[1] 任海琴[1] 宫立国[1] 刘吉[1] 李宝山[1] 于洪君[1] 任丽[1] 

机构地区：[1]沈阳东方医疗集团菁华医院生殖中心,沈阳110005

出　　处：《中国优生与遗传杂志》2013年第2期105-106,100,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨D3移植后姊妹胚胎的囊胚形成潜能与妊娠结局的关系。方法囊胚序贯培养1336例IVF-ET剩余胚胎至囊胚期,观察记录囊胚形成的情况,并统计妊娠结局。结果 (1)有囊胚形成组的临床妊娠率和种植率明显高于无囊胚形成组,流产率明显低于无囊胚形成组,两组的多胎率相似。(2)有囊胚形成的1085个周期中,Group1(囊胚形成率≥50%)临床妊娠率及种植率最高,流产率最低(47.79%,29.34%,9.23%);Group3(囊胚形成率囊<25%)临床妊娠率及种植率最低,流产率最高(32.33%,19.05%,15.60%);三组的双/多胎率无明显差别。结论姊妹胚胎在体外的囊胚形成能力是评价植入胚胎的发育潜能和预测妊娠结局的有效指标。Objective： To explore the relationship between the developmental potential of surplus embryos during D3 IVF-ET cycles and the pregnancy outcome.Methods： All surplus embryos from 1336 IVF-ET cycles were cultured into blastula by the sequential method.The relationship was analyzed between the blastula formation and the pregnancy outcome.Results： 1） The group that surplus embryos were formed blastulas had higher clinical pregnancy rate and implantation rate,lower abortion rate than the group that surplus embryos were not formed blastulas.Two groups had same multiple pregnancy rate.2） Among three formed blastulas groups,Group1 had highest clinical pregnancy rate and implantation rate,but the abortion rate was lowest;Group3 had lowest clinical pregnancy rate and implantation rate,but the abortion rate was highest.Three groups had same multiple pregnancy rate.Conclusion： The formed blastula potential of surplus embryos was an available method to evaluate the developmental potential of implanted embryos and predict the pregnancy outcome.

关 键 词：胚胎培养 囊胚形成率 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]