选择性α1受体阻滞剂在经尿道前列腺汽化电切术后早期的应用价值  

The efficacy of α1 receptor-blocker in the treatment of voiding symptoms after transurethral electrovaporization

作　　者：李锋[1] 

机构地区：[1]上海市第八人民医院泌尿外科,200235

出　　处：《中华老年医学杂志》2013年第2期178-179,共2页Chinese Journal of Geriatrics

摘　　要：目的观察选择性∞受体阻滞剂对经尿道前列腺汽化电切（TuVP）术后早期患者排尿状况的疗效。方法将80例良性前列腺增生（BPH）患者随机分为试验组与对照组，每组各40例。两组患者均行TUVP术，试验组术后第1天开始服用选择性α1受体阻滞剂，对照组未服用选择性α1受体阻滞剂，记录并比较两组患者术前和术后第30天的最大尿流率（Qmax）、膀胱剩余尿量（BRu）、国际前列腺症状评分（IPSS）及生活质量（QOL）评分的变化。结果试验组术后Omax、BRU、IPSS评分及QOL评分分别为（20．35±1．62）ml／s、（11．25±5．02）m1、（4．91±1．30）分及（1．13±0．30）分，对照组分别为（13．69±1．14）ml／s、（21．56±8．23）ml、（10．75±2．10）分及（2．75±1．13）分，较术前试验组（3．92±1．20）ml／s、（529．24±7．19）ml、（31．33±2．56）分及（5．48±0．42）分，对照组（2．85±1．32）ml／s、（302．76±7．36）ml、（30．75±2．72）分及（5．15±0．55）分均有明显改善（均P〈0．05），且试验组指标的改善明显优于对照组。结论TUVP术后早期服用选择性a．受体阻滞剂对改善术后早期排尿状况有显著疗效。Objective To evaluate the clinical efficacy of of receptor blocker （ARB） in treating voiding symptoms after TUVP and investigate its mechanism. Methods A total of 80 patients with BPH were randomly divided into 2 groups （40 cases for each）. The patients in treatment group were given of receptor blocker at 1 day after TUVP for 30 days, while patients in control group did not receive ARB treatment. The indices such as Qmax, BRU, IPSS and QOL before operation versus 30 days after operation were monitored and analyzed. The therapeutic effect was compared between 2 groups. Results The changes of Qmax, IPSS, QOL and BRU after al receptor blocker treatment had significant difference between the two groups （20.35± 1.62）ml/s, （11.25±5.02）ml, （4.91±1.30）scores,（1.13±0.30） scoresvs. （3.92±1.20）ml/s,（529.24±7.19）ml,（31.33±2.56） scores, （5.48±0./12） scores, all P〈 0. 051. All the data of treatment group showed significant improvement compared with those of control group. Conclusions The C%l receptor blocker was effective in treating voiding symptoms after TUVP.

关 键 词：前列腺增生 经尿道前列腺切除术 肾上腺素能Α拮抗剂 药物疗法 

分 类 号：R699[医药卫生—泌尿科学]