从气虚血瘀论治慢性萎缩性胃炎癌前病变  

Treatment of chronic atrophic gastritis precancerous lesions from theory of qi deficiency and blood stasis

作　　者：张露[1] 沈洪[2] 周晓波[2] 沈天华[2] 刘亚军[2] 刘增巍[2] 赵崧[2] 单兆伟[2] 

机构地区：[1]南京中医药大学,江苏210029 [2]江苏省中医院

出　　处：《北京中医药大学学报（中医临床版）》2013年第1期16-20,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：江苏高校优势学科建设工程(中西医结合)资助项目;"江苏省中医药领军人才"(No.LJ200901);江苏省人事厅"六大人才高峰第六批"资助项目

摘　　要：目的通过文献整理及总结,探讨从气虚血瘀论治慢性萎缩性胃炎(CAG)癌前病变的理论依据,在此基础上观察益气活血法对CAG气虚血瘀证的临床疗效。方法进行文献整理,总结从气虚血瘀论治CAG癌前病变的理论依据。将60例CAG患者随机分为治疗组30例、对照组30例。治疗组予益气活血方口服,对照组予胃复春片口服,疗程均为6个月。观察中医症状积分、证候疗效、病理指标积分。结果从气虚血瘀论治CAG癌前病变有充分的理论依据。胃脘疼痛、胃脘痞满积分2组治疗后与本组治疗前比较均降低(P<0.01)。纳呆少食、体倦乏力、嘈杂、嗳气、大便稀溏积分治疗组治疗后与本组治疗前比较均降低(P<0.01)。胃脘痞满、纳呆少食、体倦乏力、嘈杂、嗳气积分治疗后组间比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。治疗组证候疗效优于对照组(P<0.01)。萎缩、肠化积分2组治疗后与本组治疗前比较均降低(P<0.01),萎缩积分治疗后组间比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。结论从气虚血瘀论治CAG癌前病变有充分的理论依据,益气活血方治疗CAG气虚血瘀证患者具有较好的疗效。Objective To investigate the theory basis of treating precancerous lesions of gastric cancer （PLGC） of chronic atrophic gastritis （CAG） from theory of qi deficiency and blood stasis through literature sorting out and summing up, and observe the curative effect the therapy of supplementing qi and activating blood on PLGC of CAG （syndrome of qi deficiency and blood stasis）. Methods The theory basis of treating PLGC of CAG from theory of qi deficiency and blood stasis was summed up through literature sorting out. The patients （n=60） were randomly divided into treatment group and control group （each n=30）. Treatment group was given Yiqi Huoxue Fang orally, and control group was given Weifuehun Pian orally. The therapeutic course was 6 months. The integrals of TCM symptoms, curative effect and integrals of pathological indexes were observed. Results The theory basis of treating PLGC of CAG from theory of qi deficiency and blood stasis was sufficient. The integrals of stomach duct pain and gastric stuffiness decreased in two groups after treatment （P〈0.01）. The integrals of loss of appetite, lack of strength, gastric upset, ructus and sloppy stool decreased in treatment group after treatment （P〈0.01）. The difference in the integrals of TCM symptoms had statistical significance between two groups after treatment （P〈 0.05）, and the curative effect on TCM syndromes was better in treatment group than that in control group （P〈0.01）. The integrals of gastic atrophy and intestinal metaplasia decreased in two groups after treatment （P〈0.01）. The difference in integrals of gastic atrophy had statistical significance between two groups after treatment （P〈0.05） and the curative effect was better in treatment group than that in control group. Conclusion The treatment of PLGC of CAG from theory of qi deficiency and blood stasis has sufficient theory basis, and the therapy of supplementing qi and activating blood has good curative effect on PLGC of CAG.

关 键 词：气虚血瘀 慢性萎缩性胃炎 胃癌前病变 益气活血 

分 类 号：R256.3[医药卫生—中医内科学]