Ⅰ、Ⅱ、Ⅲ、Ⅳ型胶原对磷酸钙成骨矿化体系的作用  

The Comparison of Effects of Different Types of Collagens on the Process of Calcium Phosphate Mineralization

作　　者：徐科峰 姜智[2] 徐岚[2] 周迎会[2] 吴士良[2] 

机构地区：[1]江苏省常熟市梅李人民医院骨科,江苏常熟215500 [2]苏州大学医学部生物化学与分子生物学系,江苏苏州215123

出　　处：《中国血液流变学杂志》2012年第4期570-571,共2页Chinese Journal of Hemorheology

摘　　要：该文以磷酸钙盐的生物矿化作用为着眼点，通过模拟生物体内生物矿化的实际环境，测定不同时间内Ⅰ、Ⅱ、Ⅲ、Ⅳ种不同类型胶原对磷酸钙矿化作用的影响，由以上实验可得出两个结论：1．矿化胶原的最佳原材料应为Ⅲ或I型胶原；2．胶原移植物已失去了成骨矿化活性，可以安全地移植于皮下缺损组织。In the phase of bone making,active osteoblasts secrete collagens and some other organic substances to form the non-calcifis bone bases,subsequently calcium phosphates begin to deposit on the surface of collagen fibers.The deposition of bone salts is called osteogenesis,while the initial deposition of calcium phosphates is called biological mineralization of calcium phosphates.Starting with this kind of mineralization by simulating the actual environment of biological mineralization in living things,we assayed the effect of different types of collagen on mineralization at different time,which suggests the influence on osteoblasts by collagens of different types.

关 键 词：胶原 成骨 矿化 

分 类 号：Q813[生物学—生物工程]