MMP-9，hs-CRP及WBC计数与冠心病的关系  

Relationship between Levels of MMP-9,hs-CRP and WBC Count with Coronary Heart Disease

作　　者：周志英[1] 周滔[2] 黄惠芳[1] 顾国浩[1] 金晓华[1] 翟菊萍[1] 

机构地区：[1]苏州大学附属第一医院检验科,江苏苏州215006 [2]常熟市疾病预防控制中心,江苏常熟215600

出　　处：《中国血液流变学杂志》2012年第4期687-690,共4页Chinese Journal of Hemorheology

摘　　要：目的探讨血清基质金属蛋白酶．9（MMP．9）、超敏C反应蛋白（hs—CRP）水平及外周血白细胞（WBC）计数与冠心病发生、发展的关系。方法选取冠心病患者105例作为冠心病组，包括稳定性心绞痛（SAP）组27例、不稳定性心绞痛（UAP）组48例和急性心肌梗死（AMI）组30例，测定血清MMP．9、hs．CRP浓度和外周血WBC计数，健康体检者40名为对照组。结果①冠心病各组MMP．9、hs．CRP、WBC较对照组显著增高（P〈0．01）；@AMI组血清MMP．9、hs—CRP浓度和外周血WBC计数高于其余三组（P〈0．05）；@UAP组血清MMP．9、hs—CRP浓度和外周血WBC计数高于其余二组（P〈0．05）；④SAP组血清hs—CRP浓度高于对照组（P〈O．05），血清MMP-9和外周血WBC计数高于对照组，但差异无统计学意义（P〉0．05）；@MMP．9、hs．CRP水平及WBC计数与冠心病事件的严重程度呈正相关（r=0．836，P〈0．01：r=0．672，P〈0．01；r=0．619，P〈0．01）；⑥冠心病患者血清MMP-9浓度与hs-CRP浓度及外周血WBC计数呈正相关（r=0．559，P〈0．01；r=0．553，P〈O．01）。结论血清MMP-9、hs-CRP与外周血WBC计数与冠心病不同类型及斑块稳定性有关。Objective To investigate whether levels of matrix metalloproteinase-9（MMP-9）,high sensitive C-reactive protein（hs-CRP） and white blood cell（WBC） count were affected in patients with coronary heart disease（CHD）.Methods The levels of MMP-9,hs-CRP and WBC were measured in 27 patients with stable angina pectoris（SAP）,48 patients with unstable angina pectoris（UAP）,30 patients with acute myocardial infarction（AMI） and 40 control normal subjects.Results @The levels of MMP-9,hs-CRP and WBC in AMI,UAP, and SAP groups were significantly higher than those of the control group（P 〈 0.01）.@The levels of MMP-9,hs-CRP and WBC in AMI group were markedly higher than UAP, SAP and control groups（P 〈 0.05）.@The levels of MMP-9,hs-CRP and WBC in UAP group were significantly higher than SAP and control groups（P 〈 0.05）.@The levels of hs-CRP in SAP group were significantly higher than those in control group（P 〈 0.05）,while the levels of MMP-9 and WBC had no significant difference between them（P 〉 0.05）.@The levels of MMP-9,hs-CRP and WBC were positively correlated with the severity of coronary events（r=0.836,P 〈 0.01 ;r=0.672,P 〈 0.01 ;r=0.619,P 〈 0.01）.@Significant positive correlation between the levels of MMP-9 and hs-CRP and WBC all were observed in the patients with CHD（P 〈 0.05）.Conclusion The elevation of levels of MMP-9,hs-CRP and WBC were associated with initiation and progression of CHD,and they may help predict cardiovascular events.

关 键 词：冠心病 基质金属蛋白酶 超敏C反应蛋白 白细胞计数 

分 类 号：R446.11[医药卫生—诊断学] R541.4[医药卫生—临床医学]