佛山市三水区新生儿乙肝疫苗免疫无应答影响因素分析  

Case-control study on the influencing factors of unresponsiveness of the neonates vaccinated with hepatitis B vaccine in Sanshui,District,Foshan

作　　者：唐惠英[1] 

机构地区：[1]佛山市三水区疾病预防控制中心,广东佛山528100

出　　处：《中国热带医学》2012年第12期1472-1476,共5页China Tropical Medicine

基　　金：2010年佛山市医学科学立项课题(No.2010475)

摘　　要：目的了解佛山市三水区新生儿乙肝疫苗免疫无应答的影响因素,为乙肝疫苗免疫无应答人群提供一定的参考和建议。方法对辖区幼儿园4岁年龄组(限在±半岁年龄)共608名儿童采取检测乙肝标记物,查阅免疫接种资料及电话询问等方式,筛查出符合条件的病例组,并按1:2配对方法抽查对照组。采用Logistic回归分析,计算各因素与乙肝疫苗免疫无应答关系的比值比(OR)及其95%可信区间(95%CI)。结果多因素Logistic回归分析,父亲乙肝病毒HBsAg阳性相对于父亲各项感染指标全阴时,婴儿出现免疫无应答的OR=1.645(95%CI 1.1120～2.4340),父亲乙肝病毒HBsAb阳性相对于父亲各项感染指标全阴,婴儿出现免疫无应答的OR=0.7070(95%CI 0.5180～0.9630),父亲有乙肝疫苗免疫无应答史,婴儿出现免疫无应答的OR=1.49(95%CI 1.108～2.005),第三次接种疫苗剂量,OR=2.574(95%CI1.110～5.964),婴儿用餐具消毒效果OR=1.2510(95%CI 1.009～1.5520)经以上统计分析,差异有统计学意义。结论 "父亲乙肝病毒HBsAg阳性"、"父亲有乙肝疫苗免疫无应答史"、"第三次接种疫苗剂量"、婴儿用餐具消毒效果为新生儿乙肝免疫无应答的危险因素,而"父亲HBsAb阳性"是新生儿乙肝免疫无应答的保护因素。Objective To understand the influencing factors unresponsiveness of the neonates to hepatitis B vaccine in Sanshui district of Foshan city. Methods Logistic regression analysis was used to calculate odds ratio （OR） and 95% confidence intervals （95% CI） of various factors associated with unresponsiveness of neonates to hepatitis B vaccine.. The 1：2 matching design method was used to investigate the 508 infants aged 4 years in a kindergarten by questionnaire survey. In addition, the data concerning antibody against hepatitis B virus, vaccination were confirmed by phone call. The appropriate cases were screened and assigned to observation group and control group. Results Results of multivariate logistic regression analysis show that in case the HBV sdsdHBsAb of the father was positive while other indicators were negative, then the OR of occurrence of unresponsiveness of the father＇ s infant was 1.645 （95%CI1.1120 ~ 2.4340）. if the HBV HBsAb of the father was positive while other indicators were negative, then the OR of occurrence of unresponsiveness of the father＇ s infant was 0.7070 （95% CI0.5180~0.9630）. If the father had a history of unresponsiveness to HBV then the OR of occurrence of unresponsiveness of the infant to HB vaccine was OR=1.49 （95%CI1.108 ~ 2.1305）. The OR of the third vaccination dos was 2.574 （95% CII.ll0 ~ 5.964）, the OR of disinfection effect of baby tableware was 1.2510 （95%CI1.009 ~ 1.5520）, showing significant difference. Conclusion The positive for HBsAg pof the father, the history of unresponsiveness of the father, the third vaccine dose, the disinfection results of infant tableware are the risk factors for unresponsiveness of infants to hepatitis B vaccine, while the positive for HBsAg of the father is the protective factors for unresponsiveness of the infants to hepatitis B vaccine.

关 键 词：乙肝疫苗免疫 无应答 新生儿 病例对照研究 流行病学 危险因素 

分 类 号：R186[医药卫生—流行病学]