复方珍珠膏抗炎镇痛止痒作用研究  

Anti-Inflammatory,Analgesic and Antipruritus Effects of Margarita Compound Ointment in Mice and Rats

作　　者：赵丽红[1] 冯欣[1] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100026

出　　处：《中国药学杂志》2013年第4期266-268,共3页Chinese Pharmaceutical Journal

基　　金：北京市中医药科技项目(JJ2010-10)

摘　　要：目的研究复方珍珠膏的抗炎镇痛止痒作用。方法通过小鼠组织修复模型及毛细血管通透性增高模型评价复方珍珠膏的抗炎效果;采用醋酸扭体实验评价镇痛效果;采用右旋糖酐致痒模型观察药物的止痒作用;并采用大鼠棉球肉芽肿实验评价抗增生效果。结果复方珍珠膏皮肤给药高剂量可缩短局部损伤创面愈合时间(P<0.05),各剂量能不同程度地降低腹腔毛细血管通透性,减少乙酸刺激引起的扭体次数,减少右旋糖酐诱导的小鼠搔痒的次数(P<0.01,P<0.05),此外,中、高剂量组可抑制大鼠肉芽肿组织的增生(P<0.01,P<0.05)。结论复方珍珠膏具有明显的抗炎、止痛和止痒作用。OBJECTIVE To study the anti-inflammatory, analgesic, and antipruritus activities of Margarita compound ointment.METHODS The anti-inflammatory activity of Margarita compound ointment was assessed by the mouse skin wound healing model and peritoneal capillary permeability increase model. The analgesic effect was tested by writhing test in mice. The antipruritus effect was e- valuated by dextran-induced itching models. And the anti-granuloma effect was observed by cotton embedding ball test in rats. RESULTS A shortened skin wound healing time of mouse was observed in the high-dose groups of Margarita compound ointment （ P 〈 0. 05 ）. Margarita compound ointment at different doses could obviously decrease the exudation of abdominal blood capillaries, the numbers of writhing of mice caused by acetic acid and scratching frequency induced by dextran （ P 〈 0. 01, 0. 05 ）. And Margarita compound ointment could inhibit the cotton ball-induced granuloma hyperplasia of rats in moderate-and high-dose groups （ P 〈 0. 01, 0. 05 ）. CONCLUSION Margarita compound ointment has anti-inflammatory, analgesic and antipruritus effects in mice and rats.

关 键 词：复方珍珠膏 抗炎 镇痛 止痒 

分 类 号：R965[医药卫生—药理学]