miR-34a在辐射损伤效应中的作用  

Effects of miR-34a on ionizing radiation injuries

作　　者：李磊[1] 陈秋[1] 崔凤梅[1] 涂彧[1] 

机构地区：[1]苏州大学医学部放射医学与防护学院,苏州215123

出　　处：《辐射研究与辐射工艺学报》2013年第1期1-5,共5页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(81172706);江苏高校优势学科建设工程资助项目(PAPD)资助

摘　　要：miR-34a位于染色体1p36.23区,作用于多种靶基因。miR-34a的异常表达可诱发细胞凋亡、周期阻滞和细胞分化,也可降低肿瘤细胞的转移,被认为是一种肿瘤抑制因子。抑癌基因p53可以激活miR-34a,miR-34a也可反馈调节p53表达。电离辐射诱导的miR-34a异常表达在DNA损伤修复、细胞凋亡、细胞周期调节和细胞辐射敏感性中发挥重要作用。本文综述电离辐射诱导miR-34a的产生及其参与的生物学反应和调控机制。miR-34a resides in the region of chromosome lp36.23, which regulate a plethora of target genes. Ectopic miR-34a expression can induce apoptosis, cell cycle arrest and differentiation, meanwhile reduce migration of tumour cell which known as tumour inhibiting factor, p53 was shown a capability of activating miR-34a expression and miR-34a was also shown a feedback regulation to p53 gene in reverse. Ectopic expression of miR-34a induced by ionizing radiation plays an important role in DNA damage repair, apoptosis, cell cycle and cellular radiation sensitivity. This article reviews the progress in produce of miR-34a during ionizing radiation and its participation in biological response and relative mechanism in control.

关 键 词：MIR-34A 电离辐射 细胞凋亡 细胞周期调节 

分 类 号：R818.74[医药卫生—放射医学] R811.5[医药卫生—临床医学]