HAART治疗对不同临床类型HIV-1感染者血清IL-18及IL-18BP水平的影响  

The effect of HAART on levels of serum IL-18 and IL-18 BP in different clinical types patients with HIV-1

作　　者：张英[1] 蒋就喜[1] 李赫伟[1] 胡婷婷[1] 徐茹 沈剑锋[3] 谢付静[4] 

机构地区：[1]桂林医学院,541001 [2]桂林市第三人民医院,541004 [3]安徽省淮南市东方医院集团总院,232007 [4]山东省聊城市人民医院,252000

出　　处：《实用医学杂志》2013年第4期627-629,共3页The Journal of Practical Medicine

基　　金：广西本级技术研究与开发项目(编号:桂财教[2010]124号;桂财教[2012]98号);广西医疗卫生重点科研课题(编号:重2010055);桂林市科学研究与技术开发项目(编号:市科[2010]37号)

摘　　要：目的:探讨高效抗逆转录病毒治疗(HAART)对不同临床类型HIV-1感染者血清白细胞介素-18(Interleukin 18,IL-18)和白细胞介素-18结合蛋白(Interleukin 18 binding protein,IL-18BP)水平的影响。方法:酶联免疫吸附法(ELISA)检测67例经12个月以上HAART治疗有效的HIV-1感染者及18例健康人的血清IL-18和IL-18BP水平。采用流式细胞术测定HIV-1感染者血液中CD4+、CD8+T细胞水平。结果:不同临床类型HIV-1感染者血清IL-18、IL-18BP水平均高于正常对照组(P<0.05);A类HIV-1感染组CD4/CD8比值高于B类、C类HIV-1感染组(P<0.05,P=0.004,0.014)。CD4+T细胞<500的两组血清IL-18、IL-18BP水平均高于正常对照组(P<0.05);正常对照组血清IL-18和IL-18BP水平呈正相关(P<0.01,r=0.705)。结论:HAART治疗不能完全逆转HIV-1感染者免疫系统失衡,但艾滋病患者早期治疗可能降低机体免疫系统失衡的程度。Objective To investigate the impact of HAART on the levels of IL-18 and IL-18BP in serum of different types HIV-I infected patients. Methods Serum samples obtained from 18 healthy subjects and 67 HIV-1 infected patients who responded well to HAART were analyzed by ELISA to determine their IL-18 and IL-18BP contents. The levels of CD4＋ T cell and CD8＋ T cell in blood of 67 HIV-1 infected patients were detected by flow cytometry. Results Compared with healthy persons, serum IL-18, IL-18BP increased in the serum of HIV-infected patients （P 〈 0.05）. The ratio of CD8 to CD4 of HIV-1 group A was higher than that of group B and C （P 〈 0.05, P = 0.004;P = 0.014）. Serum IL-18 and IL-18BP of HIV-1 groups which the levels of CD4＋ helper T cell was less than 200 were higher than the control group （P 〈 0.05 ）. A significant positive correlation was found between the levels of IL-18 and IL-18BP in healthy persons （P 〈 0.01 ,r = 0.705）. Conclusions HAART can＇t completely reverse the imbalance of HIV-1 infected patients＇ immune system. Early treatment may reduce the imbalance of immune systems.

关 键 词：HIV-1 白细胞介素-18 白细胞介素-18结合蛋白 

分 类 号：R512.91[医药卫生—内科学]