药物治疗癫痫患儿284例分析  

Analysis of 284 cases of pediatric epilepsy treated with drug therapy.

作　　者：姜永生[1] 黄绍平[1] 王雪莹[1] 汪利群[2] 

机构地区：[1]西安交通大学医学院第二附属医院小儿内科,西安710004 [2]西安市儿童医院,西安710003

出　　处：《中国实用儿科杂志》2013年第2期132-135,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的了解癫痫患儿诊治情况。方法连续录入2009年10月至2010年3月西安两家儿童癫痫专科门诊随诊的284例目标癫痫患儿治疗及控制情况，并对调查数据进行统计处理。结果284例中188例（66．2％）单药治疗，73例（25．7％）口服两种抗癫痫药物，23例（8．1％）使用多种药物抗癫痫治疗。抗癫痫新药与传统药物使用例次比为226：175。在调查之日前6个月内：186例（65．5％）无癫痫发作，其中男113例（60．4％）；98例（34．5％）仍有1次或多次发作，其中男60例（62．3％）；性别与控制情况无关联（x2=0．1，P〉0．05）；124例（43．7％）单药治疗得到控制，47例（16．5％）二联方案治疗后无发作，15例（5-3％）三联方案维持无发作状态。结论单药治疗方案可使43．7％患儿发作得到控制，合理联合应用2-3种药物能使21．8％患儿无发作。新型抗癫痫药物的使用稍高于传统药物；Objective To make a better understanding of current diagnosis and clinical management of childhood epilepsy. Methods The study population consisted of a consecutive series of appropriate children with epilepsy who visited two childhood epilepsy specialist clinics in Xi＇ an during 6 months. Data collected with self-designed questionnaire were registered into Microsoft Office Excel 2003 database, and then were performed statistical process and description. Resuits A total of 284 cases of active epilepsies were collected.A majority of the patients, 188 cases （66.2%）, were treated with monotherapy, 73 patients （25.7%） were using two kinds of antiepileptic drugs, and the remained 23 cases （8.1% ） were treated with a combination of three or four antiepileptic drugs. The ratio between first generation AEDs and new AEDs used in the cohort was 226： 175. Totally 186 cases （65.5%）had kept seizure free in the 6 months before the fol- low-up, of which 113 （60.4%）were male patients, while another 98 cases （34.5%） relapsed at times, including 60 （62.3%） male patients;there was no definite association between gender and the tcome of AEDs therapy（x2 = 0.1, P 〉 0.05）.Totally 124 （43.7%）of the cohort using monotherapy were in remission for at least 6 months, meanwhile 47 （16.5%） of the cohort using two AEDs and 15（5.3%）using three AEDs also achieved remission. Conclusion About 43.7% of the cases have kept seizure free with monotherapy in the 6 months before the follow-up, another 21.8% succeed with rational polytherapy. There are more children using new antiepileptie drugs than those using traditional antiepi- leptic drugs.

关 键 词：癫痫 儿童 抗癫痫药物 

分 类 号：R72[医药卫生—儿科]