氟哌噻吨美利曲辛联合埃索美拉唑治疗非糜烂性胃食管反流病的临床观察  

Clinical Observation of Flupentixol Melitracen Combined with Esomeprazole in the Treatment of Non-erosive Gastroesophageal Reflux Disease

作　　者：季兴[1] 黄薇薇[1] 程莉华[1] 潘程宇[2] 

机构地区：[1]南京医科大学附属南京儿童医院药学部,南京210008 [2]江苏省中西医结合医院消化科,南京210028

出　　处：《中国药房》2013年第8期711-713,共3页China Pharmacy

摘　　要：目的:观察氟哌噻吨美利曲辛联合埃索美拉唑治疗非糜烂性胃食管反流病(NERD)的临床效果。方法:将2009年1月-2011年6月某院非糜烂性胃食管反流病患者84例,随机均分为观察组与对照组:观察组给予氟哌噻吨美利曲辛联合埃索美拉唑治疗,对照组给予埃索美拉唑治疗,治疗后比较两组的治疗效果与不良反应。结果:治疗后,两组烧心、胸痛、反酸症状积分比较,差异均有统计学意义(P<0.05),观察组优于对照组。观察组有效率为90.5%(38/42),对照组为54.8%(23/42),两组比较差异有统计学意义(P<0.05)。观察组患者不良反应发生率为2.4%(1/42),对照组为11.9%(5/42),两组比较差异无统计学意义(P>0.05)。两组患者均进行了6～18个月随访,观察组患者复发率为9.5%(4/42),对照组为31.0%(13/42),两组比较差异有统计学意义(P<0.05)。结论:氟哌噻吨美利曲辛联合埃索美拉唑治疗NERD能够从精神、心理因素上对患者生活质量和精神心理异常进行干预,提高治疗效果,降低复发率。OBJECTIVE： To observe the clinical efficacy of flupentixol melitracen combined with esomeprazole in the treat- ment of non-erosive gastroesophageal reflux disease （NERD）. METHODS： 84 cases of NERD collected from a hospital during Jan. 2009--Jun. 2011 were randomly divided into observation group and control group. Observation group accepted flupentixol melitra- cen combined with esomeprazole, and control group received esomeprazole. Therapeutic efficacy and adverse drug reaction were compared between 2 groups. RESULTS： After treatment, heartburn, pectoralgia and sour regurgitation were improved; there was statistical significance （P〈0.05）. The effective rate of observation group was 90.5% （38/42）, and that of control group was 54.8% （23/42）; there was statistical significance（P〈0.05）. The incidence of ADR was 2.4% in observation group （1/42） and 11.9% in control group （5/42） ; there was no statistical significance （P〉0.05）. The follow-up period lasted for 6 months-18 months. The recurrent rate of observation group was 9.5% （4/42） and that of control group was 31.0% （13/42）; there was statisti- cal significance （P〈0.05）. CONCLUSION： Combined treatment of flupentixol melitracen and esomeprazole can intervene in the quality of life and mental psychological abnormality in NERD patients through psycho-mental factors, improve therapeutic efficacy and reduce recurrence. It helps clinical physicians intervene in NERD, which deserves further attention.

关 键 词：埃索美拉唑 非糜烂性胃食管反流病 氟哌噻吨美利曲辛 

分 类 号：R714.255[医药卫生—妇产科学]